Dynamics of the cell-mediated immune response to tumour growth

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Álvaro G LópezMiguel A F Sanjuán

Abstract

Using a hybrid cellular automaton, we investigate the transient and asymptotic dynamics of the cell-mediated immune response to tumour growth. We analyse the correspondence between this dynamics and the three phases of the theory of immunoedition: elimination, equilibrium and escape. Our results demonstrate that the immune system can keep a tumour dormant for long periods of time, but that this dormancy is based on a frail equilibrium between the mechanisms that spur the immune response and the growth of the tumour. Thus, we question the capacity of the cell-mediated immune response to sustain long periods of dormancy, as those appearing in recurrent disease. We suggest that its role might be rather to synergize with other types of tumour dormancy.This article is part of the themed issue 'Mathematical methods in medicine: neuroscience, cardiology and pathology'.

References

Jan 1, 1975·Advances in Cancer Research·O Stutman
Nov 1, 1981·British Journal of Cancer·P A GatenbyP Creswick
Mar 1, 1994·Bulletin of Mathematical Biology·V A KuznetsovA S Perelson
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·D H KaplanR D Schreiber
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mark J MillerIan Parker
Jun 6, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S C FerreiraM J Vilela
Apr 6, 1957·British Medical Journal·M BURNET
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Sep 6, 2005·Cancer Research·Lisette G de PillisCharles L Wiseman
Sep 20, 2005·Journal of Theoretical Biology·D G Mallet, L G De Pillis
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David PáezHeinz-Josef Lenz
Jun 17, 2016·PloS One·Álvaro G LópezMiguel A F Sanjuán

❮ Previous
Next ❯

Citations

May 17, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·José M Amigó, Michael Small
Sep 20, 2017·Cancer Research·Jakob Nikolas KatherNiels Halama
Oct 7, 2018·Molecular Cancer Research : MCR·Haley D AxelrodKenneth J Pienta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Oleg V MaslennikovVladimir I Nekorkin
Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Panayiotis ChristodoulidesReiko J Tanaka
Critical Care Medicine
Oriol Roca, Joan R Masclans
Journal of Mathematical Biology
S Coombes
Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Takahiro EzakiNaoki Masuda
© 2022 Meta ULC. All rights reserved