Feb 1, 1976

Dynamics of the changes in the tissular levels of cyclic AMP after cobalt-60 gamma-irradiation

Strahlentherapie
E PăuşescuT Teodosiu

Abstract

The total amounts of cyclic AMP in liver, brain and intestinal mucosa have been measured in rats, at constant intervals, up to 18 days after whole body exposure to either a unique moderate dose (500 rd) or a unique lethal dose (750 rd) of cobalt-60 gamma-radiation. This radiation, even in a lethal dose, was found to induce no significant changes in the hepatic levels of cAMP. In contrast, an abrupt short-lasting increase in the levels of cAMP was observed in brain and intestinal mucosa after a 500-rd-irradiation, and a progressive long-lasting increase in its levels in the intestinal mucosa and, especially, in the brain was found after a 750-rd-irradiation. It is concluded that these organs contain different cAMP systems, which would explain, at least in part, their dissimilar responses to the ionizing rays.

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Mentioned in this Paper

Brain
Effects of Radiation
Hepatic
Cyclic AMP
Mitochondria, Liver
Whole Body
NADH
Organ
Structure of Intestinal Gland
Cyclic Adenosine Monophosphate Measurement

About this Paper

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