Dynamics of the Multipathway Regulation of the Vasodilator Bold Effect Induced by a Nerve Impulse: A Kinetic Model of the Neurovascular Coupling Process.

ACS Chemical Neuroscience
Sergey D VarfolomeevSvetlana B Tsybenova

Abstract

A kinetic model of the dynamics of a multipathway mechanism of neurovascular coupling induced by nerve impulses was constructed. The model calculations were compared with experimental data on the changes in the blood oxygen level dependent signal during sensory-motor and visual excitation before and after the use of the nonsteroidal anti-inflammatory drug indomethacin. The influence of the catalytic activity of key enzymes on the dynamics of the neurovascular response in the proposed model is shown. The multipathway mechanism of the biochemical reactions provides stability of the neurovascular coupling during various possible catalytic activities of the key enzymes in the process.

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Mar 10, 2001·Journal of Magnetic Resonance Imaging : JMRI·H BruhnJ Frahm
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Francesco Cipollone, Carlo Patrono
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S St LawrenceA C McLaughlin
Apr 1, 1936·Proceedings of the National Academy of Sciences of the United States of America·L Pauling, C D Coryell
Mar 8, 2007·Physiological Genomics·David E StecMark J Rieder
Jun 6, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sarah GoraSonia-Athina Karabina
Dec 8, 2009·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Volker HeelmannChristoph Wedekind
May 14, 2010·Arquivos de neuro-psiquiatria·Quirino CordeiroHomero Vallada
Nov 12, 2010·Nature·David AttwellEric A Newman
Sep 6, 2011·European Heart Journal·Ulrich Förstermann, William C Sessa
Jan 17, 2012·NeuroImage·Richard B Buxton
Mar 23, 2012·Developmental Cognitive Neuroscience·Julia J HarrisDavid Attwell
Sep 18, 2012·Chemico-biological Interactions·Alexander V NemukhinSergei D Varfolomeev
Mar 15, 2013·Chemico-biological Interactions·Eugene V RozengartSergei D Varfolomeev
Jul 18, 2014·Annual Review of Neuroscience·Elizabeth M C Hillman
Mar 3, 2015·Journal of Magnetic Resonance Imaging : JMRI·Clarisse I MarkJ Jean Chen
Apr 3, 2016·Acta Neuropathologica·Axel MontagneBerislav V Zlokovic
Apr 20, 2016·The Journal of Physical Chemistry. B·Ekaterina D KotsAlexander V Nemukhin
Aug 31, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Catherine N HallAnusha Mishra
Sep 15, 2017·The Journal of Physical Chemistry. B·Maria G KhrenovaAlexander V Nemukhin
Feb 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Maosen WangXin Yu
Mar 30, 2018·Frontiers in Pharmacology·Sofya V LushchekinaPatrick Masson
Nov 28, 2018·Neuroscience and Biobehavioral Reviews·Patrick S Hosford, Alexander V Gourine
Mar 1, 2020·International Journal of Molecular Sciences·Regina F NasyrovaAlbert A Rizvanov
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard B Buxton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Experimental Medicine and Biology
U Dirnagl
Wiener medizinische Wochenschrift
M Westphal, H D Herrmann
The Journal of the American Osteopathic Association
P E THOMAS
Frontiers in Neuroenergetics
Anna Devor, David Boas
© 2021 Meta ULC. All rights reserved