Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.

AIDS
Deborah PersaudEllen G Chadwick

Abstract

Identification of HIV infection in exposed infants facilitates early therapy, which may limit viral reservoirs that maintain HIV infection under HAART. The dynamics of the resting CD4 T-cell latent HIV reservoir was determined over the first 2 years of life in 17 HIV-infected infants initiating lopinavir/ritonavir-based HAART at a median age of 8.1 weeks and achieving adequate suppression of plasma viral load by 24 weeks. The resting CD4 T-cell latent HIV reservoir was detected in 12 of 14 (86%) infants tested at 24 weeks of HAART [median frequency 1.88 infectious units per million (IUPM); range <0.22 to 81.7), and remained measurable (median IUPM = 0.32; range <0.22 to 3.25) in six of 10 (60%) children retested at 96 weeks. The reservoir declined, from 24 to 96 weeks of HAART, at an estimated mean rate of 0.028 log10 IUPM/month, corresponding to a half-life of 11 months (95% confidence interval 6-30 months]. A strong relationship was found between the frequency of latently infected CD4 T cells at 96 weeks of HAART and time to first undetectable plasma viral load (Spearman r = 0.91, P < 0.001). Although the resting CD4 T-cell latent reservoir remains detectable over the first 2 years of HAART in a substantial proportion of infa...Continue Reading

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Citations

Oct 25, 2013·The New England Journal of Medicine·Deborah PersaudKatherine Luzuriaga
Jan 7, 2014·Current HIV/AIDS Reports·Nicole H Tobin, Grace M Aldrovandi
Jun 19, 2014·Médecine sciences : M/S·Pierre FrangeMarie-Laure Chaix
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Nov 18, 2014·Current Opinion in HIV and AIDS·Kaitlin Rainwater-LovettDeborah Persaud
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Sep 17, 2013·Expert Opinion on Pharmacotherapy·Julià Blanco
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