Dynamics of the yeast transcriptome during wine fermentation reveals a novel fermentation stress response.

FEMS Yeast Research
Virginia D MarksHennie J J van Vuuren

Abstract

In this study, genome-wide expression analyses were used to study the response of Saccharomyces cerevisiae to stress throughout a 15-day wine fermentation. Forty per cent of the yeast genome significantly changed expression levels to mediate long-term adaptation to fermenting grape must. Among the genes that changed expression levels, a group of 223 genes was identified, which was designated as fermentation stress response (FSR) genes that were dramatically induced at various points during fermentation. FSR genes sustain high levels of induction up to the final time point and exhibited changes in expression levels ranging from four- to 80-fold. The FSR is novel; 62% of the genes involved have not been implicated in global stress responses and 28% of the FSR genes have no functional annotation. Genes involved in respiratory metabolism and gluconeogenesis were expressed during fermentation despite the presence of high concentrations of glucose. Ethanol, rather than nutrient depletion, seems to be responsible for entry of yeast cells into the stationary phase.

References

Oct 1, 1992·Molecular & General Genetics : MGG·C Melamed, M Kupiec
Mar 1, 1991·Journal of General Microbiology·C A Viegas, I Sá-Correia
Mar 19, 1993·Science·J L BrewsterM C Gustin
Aug 1, 1997·Molecular Biology of the Cell·M J De VitM Johnston
Feb 21, 1998·Nucleic Acids Research·J M CherryD Botstein
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·J M Gancedo
Mar 24, 1999·Trends in Genetics : TIG·M Johnston
Apr 2, 1999·European Journal of Biochemistry·R A Dennis, M T McCammon
Jul 20, 1999·Molecular and Cellular Biology·B LiJ R Warner
Nov 5, 1999·Trends in Biochemical Sciences·J R Warner
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Feb 17, 2001·Molecular Biology of the Cell·H C CaustonR A Young
May 15, 2002·FEMS Microbiology Reviews·Fernando Moreno, Pilar Herrero
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Stefan Hohmann
Aug 15, 2002·Bioinformatics·Boris Lenhard, Wyeth W Wasserman
Apr 5, 2003·The Journal of Biological Chemistry·Elton T YoungTrey Ideker
Apr 12, 2003·FEMS Yeast Research·Virginia D MarksHennie J J van Vuuren
May 16, 2003·FEMS Yeast Research·Daniel J ErasmusHennie J J van Vuuren
Jun 27, 2003·Functional & Integrative Genomics·Albin SandelinWyeth W Wasserman
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Oct 14, 2003·Eukaryotic Cell·Ian FingermanAndrew K Vershon
Dec 1, 1992·Trends in Cell Biology·L H Johnston
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang

❮ Previous
Next ❯

Citations

May 14, 2010·Applied Microbiology and Biotechnology·Menggen Ma, Z Lewis Liu
Sep 21, 2011·Applied Microbiology and Biotechnology·Debra RossouwFlorian F Bauer
Jan 7, 2009·Bioprocess and Biosystems Engineering·Thai Nho DinhHiroshi Shimizu
Oct 13, 2009·Journal of Industrial Microbiology & Biotechnology·Bing-Zhi LiYing-Jin Yuan
Sep 4, 2012·Nucleic Acids Research·Hila GingoldYitzhak Pilpel
Apr 27, 2010·Applied and Environmental Microbiology·Debra RossouwFlorian F Bauer
Jun 25, 2013·Applied and Environmental Microbiology·D RossouwF F Bauer
Aug 25, 2009·Applied and Environmental Microbiology·Debra RossouwFlorian F Bauer
Feb 25, 2014·Applied Microbiology and Biotechnology·Xiaoxia YuLiming Liu
Mar 1, 2016·Frontiers in Microbiology·Elisabet Navarro-TapiaRoberto Pérez-Torrado
Dec 12, 2012·Trends in Genetics : TIG·Anthony R BornemanIsak S Pretorius
Dec 3, 2011·International Journal of Food Microbiology·Vanessa PenachoRamon Gonzalez
Nov 30, 2015·Applied Microbiology and Biotechnology·Chiara NadaiViviana Corich
Nov 20, 2010·Current Opinion in Biotechnology·Miguel C TeixeiraIsabel Sá-Correia
Feb 28, 2009·Journal of Applied Microbiology·T RossignolB Blondin
Apr 23, 2010·Journal of Applied Microbiology·M S DahabiehH J J Van Vuuren
Nov 19, 2013·Environmental Microbiology·Laura TreuStefano Campanaro
Sep 19, 2009·Microbiology·Zongli Luo, Hennie J J van Vuuren
Aug 15, 2015·Journal of Agricultural and Food Chemistry·Matias I KinzurikBruno Fedrizzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.