PMID: 9169821Mar 15, 1997Paper

Dynamics of tumor oxygenation, CD31 staining and transforming growth factor-beta levels after treatment with radiation or cyclophosphamide in the rat 13762 mammary carcinoma

International Journal of Radiation Oncology, Biology, Physics
Y KakejiB A Teicher

Abstract

Tumors are dynamic tissues that undergo marked molecular, biochemical, and physiologic changes in response to cytotoxic anticancer therapies. Understanding the changes in tumor oxygenation and transforming growth factor-beta expression may allow improved treatment regimens to be developed. The effects of a single dose of radiation therapy (20 Gy) or a single dose of chemotherapy (cyclophosphamide, 250 mg/kg) on several molecular and physiologic parameters of the rat 13762 mammary carcinoma growing subcutaneously in female Fischer 344 rats were explored. Treatment of the tumor-bearing animals with 20 Gy of radiation killed about two logs (99%) of the 13762 tumor cells, and treatment with cyclophosphamide (250 mg/kg) killed about 1.5 logs (95%) of the 13762 tumor cells. Hypoxia, as determined by a pO2 electrode, initially decreased in the tumors of treated animals until 6 h. posttreatment and then increased, so that 24 h. after administration of the radiation therapy or the chemotherapy the number of intratumoral vessels as determined by CD31 staining increased until about 24 h after cytotoxic therapy. Transforming growth factor-beta1, measured by radioimmunoassay, peaked in the serum between 6 h and 18 h and again between 72 h a...Continue Reading

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Citations

Jun 22, 2001·Critical Reviews in Oncology/hematology·P A Burke, S J DeNardo
Feb 1, 2002·Surgery·Yoshihiro KakejiYasunori Emi
Mar 3, 2011·Molecular Cancer Research : MCR·David L SchwartzJuri Gelovani
Mar 18, 2009·Breast Cancer Research : BCR·Mary Helen Barcellos-Hoff, Rosemary J Akhurst
Oct 17, 2008·Future Oncology·Yaacov Richard LawrenceAdam P Dicker
Jun 21, 2012·Cancer Metastasis Reviews·Yvette Drabsch, Peter ten Dijke
Mar 10, 1999·British Journal of Cancer·R NasuY Tanaka
Feb 10, 2018·Immunotherapy·Maureen L AliruSunil Krishnan
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K D MillerG W Sledge
Jun 28, 2018·Clinical & Experimental Metastasis·Andrew D RedfernErik W Thompson
Mar 13, 1999·International Journal of Cancer. Journal International Du Cancer·A GiatromanolakiG Fountzilas
Dec 20, 2019·Scientific Reports·Diana Cervantes-MadridBengt Hallberg
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Constantine S MitsiadesPaul G Richardson
Dec 17, 2020·Cell Biology International·Poonam YadavBhavani S Shankar

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