PMID: 7941299Jun 1, 1994Paper

Dynamics of viral spread in bluetongue virus infected calves

Veterinary Microbiology
S M Barratt-Boyes, N J MacLachlan

Abstract

The kinetics of viremia and sites of viral replication in bluetongue virus (BTV) infected calves were characterized by virus isolation, serology and immunofluorescence staining procedures. In addition, the role of the regional lymph node and lymphatics draining inoculated skin in the pathogenesis of BTV infection was determined by analyzing efferent lymph collected from indwelling cannulas. Viremia persisted for 35 to 42 days after inoculation (DAI) and virus co-circulated with neutralizing antibodies for 23 to 26 days. Virus was first isolated from peripheral blood mononuclear (PBM) cells at 3 DAI, after stimulation of PBM cells with interleukin 2 and mitogen. BTV was frequently isolated from erythrocytes, platelets and stimulated PBM cells but never from granulocytes and rarely from plasma during viremia. Virus was consistently isolated from erythrocytes late in the course of viremia. Interruption of efferent lymph flow by cannulation delayed the onset of viremia to 7 DAI. BTV was infrequently isolated from lymph cells, and few fluorescence positive cells were observed after lymph and PBM cells were labelled with a BTV-specific monoclonal antibody. Virus was isolated from spleen by 4 DAI and most tissues by 6 DAI, whereas vir...Continue Reading

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Citations

Jun 8, 2010·Journal of Molecular Evolution·Giovanna CarpiAndrew Kitchen
Aug 1, 1994·Comparative Immunology, Microbiology and Infectious Diseases·N J MacLachlan
Mar 1, 1995·Veterinary Immunology and Immunopathology·S M Barratt-BoyesN J MacLachlan
Jul 10, 2013·Veterinary Microbiology·Andrea VögtlinBarbara Thür
Jun 17, 2000·Journal of Virological Methods·A ClavijoA Afshar
Jul 8, 2011·Transboundary and Emerging Diseases·H AliA Cepica
Jun 26, 2009·Journal of Virology·Behzad HematiIsabelle Schwartz-Cornil
Sep 15, 2012·Virology Journal·Peter CoetzeeMoritz Van Vuuren
Apr 5, 2011·Research in Veterinary Science·Jeannette PlanzerBarbara Thür
Nov 29, 2011·Veterinary Immunology and Immunopathology·R ChannappanavarA B Pandey
Feb 17, 2010·Journal of Comparative Pathology·P J Sánchez-CordónJ C Gómez-Villamandos
Feb 16, 2010·Veterinary Microbiology·Gabriella WorwaBarbara Thür
May 30, 2009·The Veterinary Journal·Fabiana Dal PozzoEtienne Thiry
Aug 20, 2010·The Journal of General Virology·Eva Calvo-PinillaJavier Ortego
May 2, 2012·Veterinary Research·Karin E DarpelPeter Pc Mertens
Oct 9, 2013·Virus Research·Javier OrtegoAlejandro Marín-López
Dec 29, 2013·Virus Research·Avnish Patel, Polly Roy
Jan 28, 2014·Virus Research·Peter CoetzeeMaria Stokstad
Apr 23, 2011·Veterinary Immunology and Immunopathology·Channakeshava Sokke UmeshappaAnil Kumar Sharma
Sep 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eleonora MelziMassimo Palmarini
Mar 13, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R S SingerT E Carpenter
Sep 10, 2014·Viruses·Bjorn-Patrick Mohl, Polly Roy
Jul 6, 2014·Journal of Virology·Marco CaporaleMassimo Palmarini
May 23, 2008·Veterinary Research·Isabelle Schwartz-CornilStéphan Zientara
Dec 20, 2008·Veterinary Research·Anthony WilsonPeter Paul Clement Mertens
Dec 12, 2019·Frontiers in Veterinary Science·Piet A van Rijn
Dec 12, 2020·Scientific Reports·Moh A AlkhamisJosé M Sánchez-Vizcaíno

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