Dynamin GTPase, a force-generating molecular switch

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
D E Warnock, Sandra L Schmid

Abstract

Dynamin is a GTPase that regulates late events in clathrin-coated vesicle formation. Our current working model suggests that dynamin is targeted to coated pits in its unoccupied or GDP-bound form, where it is initially distributed uniformly throughout the clathrin lattice. GTP/GDP exchange triggers its release from these sites and its assembly into short helices that encircle the necks of invaginated coated pits like a collar. GTP hydrolysis, which is required for vesicle detachment, presumably induces a concerted conformation change, tightening the collar. Unlike most of its GTPase cousins that serve as molecular switches, dynamin has a low affinity for GTP, a very high intrinsic rate of GTP hydrolysis and functions as a homo-oligomer. A concerted conformational change resulting from coordinated GTP hydrolysis by the dynamin oligomer might be sufficient to generate force. In this case, dynamin would be the first GTPase identified that acts as a structural protein with mechano-chemical function.

References

Nov 1, 1990·Journal of Neurogenetics·Y T Kim, C F Wu
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I KessellT F Roth
Jan 24, 1973·Molecular & General Genetics : MGG·T A GrigliattiD T Suzuki
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J S HerskovitsR B Vallee
Aug 1, 1994·Trends in Neurosciences·P J RobinsonT C Südhof
Jun 2, 1995·The Journal of Biological Chemistry·M SchwemmleP Staeheli
Apr 1, 1995·Current Biology : CB·B J Mayer, M J Eck
Aug 1, 1995·The Journal of Cell Biology·A E GammieM D Rose
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·B BergerP S Kim
Apr 28, 1995·The Journal of Biological Chemistry·L H WangR G Anderson
Oct 1, 1994·Current Biology : CB·A K DowningM D Waterfield
Nov 1, 1994·The Journal of Cell Biology·H DamkeS L Schmid
Aug 1, 1993·The Journal of Cell Biology·A M van der BliekS L Schmid
Dec 1, 1993·Journal of Neurogenetics·M RamaswamiK S Krishnan
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·T A CookM A McNiven
Aug 1, 1993·The Journal of Cell Biology·J S HerskovitsR B Vallee
Jan 1, 1993·The Journal of Cell Biology·L L CarterS L Schmid
Oct 1, 1995·Endocrine Reviews·J P Liu, P J Robinson
Jan 5, 1996·The Journal of Biological Chemistry·H S ShpetnerR B Vallee
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·C DavidP de Camilli
Oct 1, 1995·Current Opinion in Neurobiology·P De CamilliP S McPherson
Jan 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Shaw
May 1, 1996·The Journal of Cell Biology·J R Henley, M A McNiven
Jun 24, 1996·FEBS Letters·H Damke
May 1, 1996·Journal of Neurochemistry·J P LiuP J Robinson
Sep 13, 1996·The Journal of Biological Chemistry·D E WarnockS L Schmid
Jan 1, 1995·Cold Spring Harbor Symposia on Quantitative Biology·T BabaD E Warnock
Feb 1, 1995·Trends in Cell Biology·R B Vallee, P M Okamoto

❮ Previous
Next ❯

Citations

Apr 24, 2001·Muscle & Nerve·E A Fon, R H Edwards
Apr 19, 2013·Plant Molecular Biology·Ingrid HoltsmarkSimon Geir Møller
Nov 5, 2003·Advanced Drug Delivery Reviews·Silvia R da CostaSarah F Hamm-Alvarez
Jul 2, 1999·Biophysical Journal·M M Kozlov
Apr 17, 1999·Cellular Signalling·L WunderlichL Buday
Oct 18, 2002·Current Opinion in Cell Biology·Sanja Sever
Aug 28, 1998·Current Opinion in Cell Biology·S L SchmidP De Camilli
May 14, 1999·Current Opinion in Structural Biology·J E Hinshaw
Mar 1, 2000·Trends in Biochemical Sciences·M A McNivenY Yoon
Jul 20, 2002·Seminars in Cell & Developmental Biology·Kenneth M Cadigan
Nov 30, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D J VestalG C Sen
Apr 11, 2001·Molecular Biology of the Cell·S A PredescuG E Palade
Sep 3, 1998·Molecular Biology of the Cell·H CaoM A McNiven
Jan 10, 1998·The EMBO Journal·A B MuhlbergS L Schmid
Mar 5, 2003·The Plant Cell·Shin-ya MiyagishimaTsuneyoshi Kuroiwa
Dec 16, 1998·Immunological Reviews·J M Penninger, T W Mak
Aug 10, 2000·Journal of Virology·C JanzenO Haller
Aug 23, 2006·Molecular and Cellular Biology·Anke HartungPetra Knaus
Oct 9, 2013·Annual Review of Cell and Developmental Biology·Jeremy S Rossman, Robert A Lamb
Jan 1, 1997·Annual Review of Biochemistry·S L Schmid
Dec 28, 1999·Annual Review of Cell and Developmental Biology·M J HannahW B Huttner
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J E Hinshaw
Jun 12, 2008·PloS One·Joshua Z RappoportSanford M Simon
Sep 4, 2013·Molecular Neurobiology·Longze ShaQi Xu
Apr 27, 2001·Biochemical and Biophysical Research Communications·M J JeongM Y Han
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jingling LiaoQuyen Q Hoang
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·G Kochs, O Haller
Jan 19, 1999·Annual Review of Cell and Developmental Biology·G J Hermann, J M Shaw
Jul 13, 2000·The Journal of Cell Biology·K N FishH Damke
Aug 12, 1998·The Journal of Cell Biology·M N SeamanS D Emr
Oct 24, 1998·The Journal of Cell Biology·D OtsugaJ M Shaw
Dec 29, 1998·The Journal of Cell Biology·Y AltschulerS L Schmid
May 16, 1998·The Journal of Cell Biology·J R HenleyM A McNiven
Aug 6, 2000·Journal of Neurogenetics·R R Staples, M Ramaswami
Mar 27, 2001·The Journal of Cell Biology·E HillE Smythe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved