Dynamin-related protein inhibitor downregulates reactive oxygen species levels to indirectly suppress high glucose-induced hyperproliferation of vascular smooth muscle cells

Biochemical and Biophysical Research Communications
Alimujiang MaimaitijiangYong Li

Abstract

Hyperproliferation of vascular smooth muscle cells is a pathogenic mechanism common in diabetic vascular complications and is a putatively important therapeutic target. This study investigated multiple levels of biology, including cellular and organellar changes, as well as perturbations in protein synthesis and morphology. Quantitative and qualitative analysis was utilized to assess the effect of mitochondrial dynamic changes and reactive oxygen species(ROS) levels on high-glucose-induced hyperproliferation of vascular smooth muscle cells. The data demonstrated that the mitochondrial fission inhibitor Mdivi-1 and downregulation of ROS levels both effectively inhibited the high-glucose-induced hyperproliferation of vascular smooth muscle cells. Downregulation of ROS levels played a more direct role and ROS levels were also regulated by mitochondrial dynamics. Increased ROS levels induced excessive mitochondrial fission through dynamin-related protein (Drp 1), while Mdivi-1 suppressed the sensitivity of Drp1 to ROS levels, thus inhibiting excessive mitochondrial fission under high-glucose conditions. This study is the first to propose that mitochondrial dynamic changes and ROS levels interact with each other and regulate high-gl...Continue Reading

References

Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Aug 24, 2004·Nature Cell Biology·Kuang-Hueih ChenJian Tang
Nov 18, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C BellinP Rösen
Jun 8, 2007·The Journal of Biological Chemistry·Chuang-Rung Chang, Craig Blackstone
Jun 15, 2007·The Journal of Biological Chemistry·Tao ShenRui-Ping Xiao
Sep 28, 2007·The American Journal of Cardiology·William S Weintraub
Jan 2, 2009·American Journal of Physiology. Cell Physiology·Shyamali BasuroyHelena Parfenova
Jan 31, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Victor NovackDonald E Cutlip
Mar 14, 2009·Journal of Molecular and Cellular Cardiology·Jennifer Hom, Shey-Shing Sheu
Mar 2, 2013·Current Pharmaceutical Design·Teresa Vanessa FiorentinoFranco Folli
Jun 7, 2014·Canadian Journal of Physiology and Pharmacology·Srikanth GivvimaniSuresh C Tyagi
Dec 3, 2014·Biochemical and Biophysical Research Communications·Ivan ZajaZeljko J Bosnjak

❮ Previous
Next ❯

Citations

Mar 10, 2017·Nature Reviews. Cardiology·Camila Lopez-CrisostoSergio Lavandero
Aug 27, 2017·Developmental Neurobiology·George Smith, Gianluca Gallo
Apr 28, 2018·Circulation Research·Steven J ForresterKathy K Griendling
Feb 13, 2017·Cardiovascular Drugs and Therapy·Sang-Bing OngDerek John Hausenloy
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Peng GaoZhiming Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.