Dynein light chain Tctex-1 identifies neural progenitors in adult brain.

The Journal of Comparative Neurology
Carlos DedesmaChing-Hwa Sung

Abstract

The identity and biology of stem cells and progenitors in the adult brain are of considerable interest, because these cells hold great promise for the development of novel therapies for damaged brain tissue in human diseases. This research field critically needs biological markers that specifically identify the resident precursors in the germinal zones of the adult central nervous system so that the discovery of regulatory influences for adult neurogenesis may be facilitated. In this study, by using a combination of in situ hybridization, bromodeoxyuridine incorporation, immunocolocalization, and ultrastructural studies, we show that in rodents Tctex-1, a cytoplasmic dynein light chain, is selectively enriched in almost all cycling progenitors and young neuronal progeny, but not in mature granular cells and astrocytes, in the subgranular zone of the adult dentate gyrus. Tctex-1 is also selectively abundant in cells closely resembling previously described immature progenitors and migrating neuroblasts at the subventricular zone of the lateral ventricle. Our results suggest that Tctex-1 serves as a novel marker for the identification of neural progenitors of the adult brain.

References

Jan 1, 1991·Annual Review of Neuroscience·R B Vallee, G S Bloom
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Oct 16, 1995·The Journal of Comparative Neurology·M A GatesD A Steindler
Dec 13, 1996·The Journal of Biological Chemistry·S M KingK K Pfister
Jan 1, 1997·Molecular and Cellular Neurosciences·T D PalmerF H Gage
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, P Rakic
Aug 28, 1999·The Journal of Comparative Neurology·N B Hastings, E Gould
Sep 24, 1999·Nature Neuroscience·H A Cameron, R D McKay
Jan 29, 2000·Brain Research. Molecular Brain Research·S LinnarssonP Ernfors
Feb 5, 2000·Developmental Neuroscience·W Li, J J LoTurco
Aug 18, 2000·The European Journal of Neuroscience·E Fuchs, E Gould
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Feb 17, 2001·Molecular and Cellular Neurosciences·A KawaguchiH Okano
Jun 27, 2001·The Journal of Cell Biology·A W TaiC H Sung
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·Y YagitaM Matsumoto
Jan 17, 2002·Cell·Davide SalinaBrian Burke
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Apr 12, 2002·Brain Research. Developmental Brain Research·Christiana M Cooper-Kuhn, H Georg Kuhn
May 3, 2002·Nature·Hongjun SongFred H Gage
Sep 3, 2002·Journal of Neuroscience Research·Yoshiki YagitaMasayasu Matsumoto
May 6, 2003·Science·Majid HafezparastElizabeth M C Fisher
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Nov 19, 2003·The Journal of Comparative Neurology·Golo KronenbergGerd Kempermann
Jan 6, 2004·Journal of Neurobiology·Richard B ValleeLora E Barnhart
Jan 20, 2004·The Journal of Comparative Neurology·John L MignoneGrigori Enikolopov
Apr 15, 2004·Current Opinion in Neurobiology·Gerd KempermannFred H Gage

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Citations

Mar 15, 2011·The European Journal of Neuroscience·Jagroop Dhaliwal, Diane C Lagace
Oct 4, 2011·Cell Cycle·Ching-Hwa Sung, Aiqun Li
Dec 23, 2014·Neurotoxicology·Francisco Javier Sánchez-MartínAlvaro Puga
Oct 4, 2015·Molecular & Cellular Proteomics : MCP·Sivankutty InduPradeep G Kumar
Jun 23, 2011·Reproductive Sciences·Xin HuangQing-Yuan Sun
May 19, 2009·Nature Neuroscience·Andrée Gauthier-FisherFreda D Miller
May 6, 2017·Frontiers in Biology·Fatih Semerci, Mirjana Maletic-Savatic
Feb 7, 2012·Archives of Biochemistry and Biophysics·Virgil Muresan, Zoia Muresan
Jan 11, 2022·The Journal of Cell Biology·Bryony BraschiStephen M King

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