PMID: 9655606Jul 9, 1998Paper

Dynorphin uses a non-opioid mechanism to potentiate N-methyl-D-aspartate currents in single rat periaqueductal gray neurons

Neuroscience Letters
S L LaiL Y Huang

Abstract

The interaction of the endogenous K-opioid, dynorphin, with N-methyl-D-aspartate (NMDA) receptors was studied in single periaqueductal gray (PAG) cells using the whole cell patch recording technique. We have found that dynorphin A (1-17) rapidly and reversibly potentiates NMDA-activated currents in a subpopulation of PAG cells. The potentiation cannot be blocked by the non-specific opioid antagonist, naloxone, nor can it be reversed by the specific kappa-opioid antagonist, nor-BNI. In addition, the non-opioid fragment of dynorphin, dynorphin A (2-17), is effective in potentiating NMDA currents, while the specific kappa-opioid, U50,488, cannot mimic the action of dynorphin A (1-17). The non-opioid dynorphin action and the rapid onset and recovery of the potentiation are consistent with the idea that dynorphin interacts directly with NMDA receptors in PAG cells.

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Citations

May 30, 2002·Progress in Neurobiology·Mark J Millan
Dec 11, 2003·Molecular and Cellular Neurosciences·Yoshio KanemitsuLi Zhang
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas W Sherwood, Candice C Askwith
Jun 2, 2009·Pharmacology & Therapeutics·Christoph Schwarzer
May 13, 2008·Neuroscience Letters·Gonzalo HerradonLuis F Alguacil
May 3, 2008·Neuroscience Letters·Josephine LaiFrank Porreca
May 12, 2004·Life Sciences·Mária Wollemann, Sándor Benyhe
Jan 17, 2002·Cell·Hai-Ying M ChengJosef M Penninger
Aug 30, 2000·Pain·R M Caudle, A J Mannes
Jul 27, 2000·Annals of the New York Academy of Sciences·M H OssipovF Porreca
Mar 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christian B BorgStephan A Pless
Nov 12, 2020·Journal of Neurology·Fan WuJing Bai

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