Dysautonomia is associated with structural and functional alterations in Parkinson disease

Neurology
Seok Jong ChungPhil Hyu Lee

Abstract

To investigate whether the presence of autonomic dysfunction is associated with white matter and functional connectivities and the level of cognitive performance in patients with de novo Parkinson disease (PD). Seventy-five patients with de novo PD underwent a comprehensive autonomic function test and were classified into 2 groups according to the Composite Autonomic Severity Score (CASS; 30 with moderate to severe autonomic dysfunction [CASS 4-10, PD-AUT+] and 45 without significant autonomic dysfunction [CASS 0-3, PD-AUT-]). Network-based statistics and a graph theoretical analysis were performed to assess the interregional white matter connectivity using diffusion tensor imaging. We also performed analyses of resting-state functional connectivity and compared cognitive performance between the 2 groups. There were no significant differences in demographic characteristics and vascular risk factors between the PD-AUT+ and PD-AUT- groups. The PD-AUT+ group showed poorer cognitive performance on frontal/executive function than the PD-AUT- group. The PD-AUT+ group exhibited severely disrupted white matter connectivity in both fronto-subcortical and posterior cortical regions, which was well correlated with the severity of autonomi...Continue Reading

References

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Sep 12, 2006·Parkinsonism & Related Disorders·Spiridon Papapetropoulos, Deborah C Mash
Sep 1, 2007·NeuroImage·John Ashburner
Oct 19, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·U WüllnerUNKNOWN KNP e.V
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Nov 13, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W P Cheshire
Mar 13, 2010·Archives of Gerontology and Geriatrics·Eung Seok OhAe Young Lee
Jul 6, 2010·NeuroImage·Andrew ZaleskyEdward T Bullmore
Apr 16, 2011·Human Brain Mapping·Takaaki HattoriHidehiro Mizusawa
Jul 27, 2011·Journal of Visualized Experiments : JoVE·Peter Novak
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Mar 23, 2012·Developmental Cognitive Neuroscience·Julia J HarrisDavid Attwell
Jun 27, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Silvia Rios RomenetsRonald B Postuma
Aug 2, 2012·Journal of Neurology·Manuela PilleriAngelo Antonini
Dec 12, 2012·Frontiers in Neuroinformatics·Jesse A BrownSusan Y Bookheimer
Jan 25, 2013·Journal of Clinical Neurology·Phillip A LowKi-Jong Park
Apr 5, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaJacques Montplaisir
Jan 3, 2014·Parkinsonism & Related Disorders·Jung Bin KimKun-Woo Park
Apr 17, 2014·Brain : a Journal of Neurology·Leigh ChristopherAntonio P Strafella
Aug 29, 2014·Human Brain Mapping·Hugo-Cesar BaggioCarme Junqué
Aug 31, 2014·Neurology·Julius B M AnangRonald B Postuma
Feb 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Roberto ErroPaolo Barone
Aug 13, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaThomas G Beach
Dec 8, 2015·Parkinsonism & Related Disorders·Andrew D RobertsonMario Masellis
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
Apr 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Claire McDonaldDavid J Burn
Sep 11, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Sean J UdowMario Masellis
Nov 27, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-S KimK-S Lee
Feb 25, 2017·Oxidative Medicine and Cellular Longevity·Meng-Hsiang ChenWei-Che Lin
Mar 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·TaeHee Kim, Raghu Vemuganti
May 4, 2017·Human Brain Mapping·Xingfeng LiDorothee P Auer
Jul 20, 2017·Nature Reviews. Neuroscience·Anthony H V SchapiraPeter Jenner

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Citations

Feb 26, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Seok Jong ChungYoung H Sohn
May 16, 2020·Molecular Psychiatry·Massimo FilippiFederica Agosta
Mar 15, 2020·Journal of Neurology·Rocío Del PinoJuan Carlos Gómez-Esteban
Oct 20, 2020·Journal of Parkinson's Disease·Yang Hyun LeePhil Hyu Lee
Jul 20, 2021·Journal of Parkinson's Disease·Han Soo YooPhil Hyu Lee
Sep 15, 2021·Journal of Neuroscience Research·Seok Jong ChungPhil Hyu Lee

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