Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain

The Journal of Biological Chemistry
M A BensonD J Blake

Abstract

The dystrophin-associated protein complex (DPC) is required for the maintenance of muscle integrity during the mechanical stresses of contraction and relaxation. In addition to providing a membrane scaffold, members of the DPC such as the alpha-dystrobrevin protein family are thought to play an important role in intracellular signal transduction. To gain additional insights into the function of the DPC, we performed a yeast two-hybrid screen for dystrobrevin-interacting proteins. Here we describe the identification of a dysbindin, a novel dystrobrevin-binding protein. Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus. These findings have implications for the molecular pathology of Duchenne muscular dystrophy and may provide ...Continue Reading

References

Oct 1, 1992·The Journal of Cell Biology·T S KhuranaL M Kunkel
May 24, 1991·Science·A LupasJ Stock
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·D J BlakeK E Davies
Feb 1, 1995·The Journal of Cell Biology·C PasternakE L Elson
Feb 1, 1995·The Journal of Cell Biology·A H Ahn, L M Kunkel
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B J PetrofH L Sweeney
Jan 1, 1995·Human Molecular Genetics·E OzawaS Noguchi
Mar 29, 1996·The Journal of Biological Chemistry·D J BlakeK E Davies
Apr 1, 1997·Current Opinion in Neurology·V Straub, K P Campbell
Jan 1, 1997·Progress in Brain Research·D JaarsmaJ Voogd
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Oct 23, 1997·Current Opinion in Neurology·M Michalak, M Opas
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·H M Sadoulet-PuccioL M Kunkel
Feb 12, 1998·The Journal of Biological Chemistry·M F PetersS C Froehner
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·D J BlakeK E Davies
May 21, 1999·The European Journal of Neuroscience·M BlankS Kröger
Nov 5, 1999·The Journal of Cell Biology·D J BlakeP W Beesley
Nov 13, 1999·Nature Cell Biology·D S Bredt
Jan 12, 2000·The Journal of Cell Biology·T G ThompsonL M Kunkel
Feb 17, 2000·Trends in Neurosciences·D J Blake, S Kröger

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Citations

Jul 3, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karl J A McCullaghKay E Davies
Jun 12, 2013·Histochemistry and Cell Biology·Elsa Tsoupri, Yassemi Capetanaki
Dec 17, 2008·Journal of Inherited Metabolic Disease·I A Rodriguez-Fernandez, E C Dell'Angelica
Jul 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathleen M GrantRick A Bevins
Jul 21, 2004·Current Psychiatry Reports·Brian H Shirts, Vishwajit Nimgaonkar
Apr 27, 2011·Molecular Neurobiology·Ariana P MullinVictor Faundez
Sep 18, 2004·Schizophrenia Research·Hsiao-Mei Liao, Chia-Hsiang Chen
Aug 6, 2003·Neuromuscular Disorders : NMD·K J JonesK N North
Oct 8, 2008·Development and Psychopathology·Katherine H KarlsgodtTyrone D Cannon
Jul 30, 2008·Molecular Psychiatry·A Y GuoZ Zhao
Sep 15, 2006·Nature Reviews. Molecular Cell Biology·Kay E Davies, Kristen J Nowak
Feb 24, 2006·European Journal of Human Genetics : EJHG·Maria Karayiorgou, Joseph A Gogos
Sep 21, 2005·Molecular Psychiatry·T L PetryshenP Sklar
Nov 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lisha ShaoYi Zhong
Jun 10, 2010·The Journal of Biological Chemistry·Benedetta ArtegianiPompeo Macioce
Oct 6, 2010·The Journal of Biological Chemistry·Erkang FeiGuanghui Wang
Sep 4, 2003·Human Molecular Genetics·Michael C O'DonovanMichael J Owen
Apr 8, 2009·Human Molecular Genetics·Matthew LockeDerek J Blake
Oct 30, 2009·Psychiatric Genetics·Lingjun ZuoJoel Gelernter
Jan 19, 2006·Nihon rinsho. Japanese journal of clinical medicine·Masanari Itokawa, Takeo Yoshikawa
May 10, 2006·Genes, Brain, and Behavior·M J van Belzen, P Heutink
Jun 1, 2009·Acta Neuropsychiatrica·Paolo OlgiatiAlessandro Serretti
Dec 8, 2009·Science·Dion K Dickman, Graeme W Davis
May 5, 2004·The Journal of Clinical Investigation·Konrad TalbotSteven E Arnold

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