Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1

Biochemistry
Haishan YinJeff Kuret

Abstract

Casein kinase-1 is a family of ubiquitous eukaryotic protein kinases that frequently function in tandem with the ubiquitin modification system to modulate protein turnover and trafficking. In Alzheimer's disease, these enzymes colocalize with ubiquitinated lesions, including neurofibrillary tangles and granulovacuolar degeneration bodies, suggesting they also play a role in disease pathogenesis. To identify binding partners that potentially regulate or recruit these enzymes toward disease lesions, a Sos-recruitment yeast two-hybrid screen was performed with human Ckidelta (the casein kinase-1 isoform most closely linked to granulovacuolar degeneration bodies) and a human brain cDNA library. All interacting clones contained a single open reading frame termed casein kinase-1 binding protein (CK1BP). On the basis of sequence alignments, CK1BP was a structural homologue of the acidic domain of dysbindin, a component of the dystrophin-associated protein complex and the biogenesis of lysosome-related organelles complex-1. CK1BP interacted with full-length Ckidelta, the isolated Ckidelta catalytic domain, Ckigamma2, -gamma3, and -epsilon in the yeast two-hybrid system, and bound Ckidelta and -epsilon in pulldown assays but did not int...Continue Reading

References

Jan 6, 1981·Biochemistry·S W Provencher, J Glöckner
Sep 15, 1995·The Journal of Biological Chemistry·P R Graves, P J Roach
Aug 15, 1993·Archives of Biochemistry and Biophysics·A VancuraJ Kuret
Apr 5, 1996·Journal of Molecular Biology·K L LongeneckerT D Hurley
Dec 20, 1996·The Journal of Biological Chemistry·G CarmelJ Kuret
Jul 1, 1997·Journal of Protein Chemistry·A F ChaffotteM E Goldberg
Oct 9, 1999·The American Journal of Pathology·N GhoshalJ Kuret
Feb 13, 2002·Current Opinion in Structural Biology·Warren L DeLano
Mar 5, 2002·The Journal of Biological Chemistry·Erik J EideDavid M Virshup
Jun 14, 2002·FEBS Letters·Thierry DuboisAlastair Aitken
Mar 20, 2003·Journal of Proteome Research·Olga TcherkasskayaVladimir N Uversky
Sep 25, 2003·The Journal of Biological Chemistry·Mihaela NeculaJeff Kuret
Dec 23, 2003·The Journal of Biological Chemistry·Matthew A BensonDerek J Blake
Mar 9, 2004·Biochemical and Biophysical Research Communications·Eva ZemlickovaThierry Dubois
Sep 18, 2004·The Journal of Biological Chemistry·Shuichi KaniYasuhiro Minami
Feb 3, 2005·The Journal of Cell Biology·Tracy J LaGrassa, Christian Ungermann

❮ Previous
Next ❯

Citations

Dec 17, 2008·Journal of Inherited Metabolic Disease·I A Rodriguez-Fernandez, E C Dell'Angelica
Jul 19, 2013·PloS One·Joachim BischofUwe Knippschild
Aug 21, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Wei LiXin He
Oct 13, 2014·Molecular Cancer·Birgit Schittek, Tobias Sinnberg
Jun 7, 2014·Frontiers in Oncology·Uwe KnippschildJoachim Bischof

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alzheimer's Disease: Endosomes

Dysfunctional endosomal trafficking may be associated with Alzheimer’s disease (AD) pathology. Targeting the endosome may advance treatment options for AD. Here is the latest research on endosomes and AD.