Dysbiosis associated with acute helminth infections in herbivorous youngstock - observations and implications

Scientific Reports
Laura E PeacheyCinzia Cantacessi

Abstract

A plethora of data points towards a role of the gastrointestinal (GI) microbiota of neonatal and young vertebrates in supporting the development and regulation of the host immune system. However, knowledge of the impact that infections by GI helminths exert on the developing microbiota of juvenile hosts is, thus far, limited. This study investigates, for the first time, the associations between acute infections by GI helminths and the faecal microbial and metabolic profiles of a cohort of equine youngstock, prior to and following treatment with parasiticides (ivermectin). We observed that high versus low parasite burdens (measured via parasite egg counts in faecal samples) were associated with specific compositional alterations of the developing microbiome; in particular, the faecal microbiota of animals with heavy worm infection burdens was characterised by lower microbial richness, and alterations to the relative abundances of bacterial taxa with immune-modulatory functions. Amino acids and glucose were increased in faecal samples from the same cohort, which indicated the likely occurrence of intestinal malabsorption. These data support the hypothesis that GI helminth infections in young livestock are associated with signific...Continue Reading

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Citations

Dec 22, 2019·Animals : an Open Access Journal From MDPI·Eva TydénSara Ringmark
Sep 14, 2020·Equine Veterinary Journal·Nicola WalsheVivienne Duggan
Dec 10, 2020·Animals : an Open Access Journal From MDPI·Nicola WalsheLaura Peachey
Mar 3, 2020·Current Opinion in Microbiology·Thomas J SharptonMichael Kent
Apr 27, 2021·Critical Reviews in Microbiology·Scott MitchellNicholas V Coleman
May 8, 2021·Frontiers in Cellular and Infection Microbiology·Nathan R AllenPeter M Brophy

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Methods Mentioned

BETA
PCR
NMR

Software Mentioned

DADA2
PERMDISP
Quantitative Insights
Simca
Calypso
LEfSe
QIIME2
Cutadapt

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