Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study

BMC Geriatrics
Vanessa StadlbauerAngela Horvath

Abstract

Dementia is an increasing public health threat worldwide. The pathogenesis of dementia has not been fully elucidated yet. Inflammatory processes are hypothesized to play an important role as a driver for cognitive decline but the origin of inflammation is not clear. We hypothesize that disturbances in gut microbiome composition, gut barrier dysfunction, bacterial translocation and resulting inflammation are associated with cognitive dysfunction in dementia. To test this hypothesis, a cohort of 23 patients with dementia and 18 age and sex matched controls without cognitive impairments were studied. Gut microbiome composition, gut barrier dysfunction, bacterial translocation and inflammation were assessed from stool and serum samples. Malnutrition was assessed by Mini Nutritional Assessment Short Form (MNA-SF), detailed information on drug use was collected. Microbiome composition was assessed by 16S rRNA sequencing, QIIME 2 and Calypso 7.14 tools. Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition. Gut permeability was increased as evidenced by increased serum diamine oxidase (DAO) levels and systemic inflammation was confirmed by increased soluble cluster o...Continue Reading

Associated Clinical Trials

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Citations

Feb 14, 2021·Biomolecules·Maria Jose Carranza-NavalAngel Del Marco
Jun 18, 2021·Frontiers in Immunology·Lynn van OlstHelga E de Vries
Jul 6, 2021·Journal of Alzheimer's Disease : JAD·David R ElmalehEran Segal
Sep 11, 2021·Molecular Nutrition & Food Research·Yen-Chun KohMin-Hsiung Pan

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Datasets Mentioned

BETA
PRJNA608281

Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT03167983

Software Mentioned

fmsb
ggcorrplot
Qiime2
LEfSe
DADA2
mice
psych
Linear Discriminant analysis Effect Size ( LEfSe )
stats
robustHD

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