PMID: 15334359Jan 1, 1987Paper

Dyserythropoeisis, sideroblasts/siderocytes and hemoglobin crystallization in a dog

Veterinary Clinical Pathology
P J CanfieldR C Ratcliffe

Abstract

Dyserythropoiesis characterized by enhanced intramedullary destruction, pathologic sideroblasts and siderocytes, and hemoglobin crystallization was detected in a female Cocker Spaniel presented for poor exercise tolerance. Examination of peripheral blood revealed intraerythrocytic crystals, granulation of erythrocytes, nucleated erythroid cells, reticulocytosis and marked variation in erythrocyte morphology in the absence of anemia. Bone marrow examination revealed sideroblasts, a low M:E ratio and evidence of enhanced intramedullary destruction of erythroid cells. Electron microscopy of peripheral blood and bone marrow confirmed pathologic mitochondrial iron accumulation in erythroid cells and the presence of intraerythrocytic hemoglobin crystals. A cause for the hematologic changes was not identified. After the animal became clinically normal, siderocytes disappeared from peripheral blood but intraerythrocytic crystals and reticulocytosis persisted.

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Citations

Jun 21, 2002·Veterinary Clinical Pathology·Douglas J Weiss, Jody Lulich
May 1, 1991·Journal of Veterinary Internal Medicine·C T HollandG S Allan
Jul 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·C B Grindem
Aug 8, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Eunju ChoiJeanine Peters-Kennedy
Feb 5, 2019·Journal of the American Veterinary Medical Association·Cyril Parachini-WinterCarolyn Gara-Boivin
May 25, 2002·Veterinary Clinical Pathology·Douglas J Weiss, Betsy Aird
May 23, 2002·Veterinary Clinical Pathology·Sandra BeaudoinMichel Desnoyers
Jan 1, 1989·Veterinary Clinical Pathology·Douglas J Weiss, T H Reidarson

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