Dysfunction in macula, retinal pigment epithelium and post retinal pathway in acute organophosphorus poisoning.

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Padmini DahanayakeVajira S Weerasinghe

Abstract

Organophosphorus (OP) insecticide poisoning is a significant health problem in South Asian countries. Although cholinergic receptors are present at the junction between photoreceptors and the retinal pigment epithelium (RPE), human studies of the effects of OP poisoning on the visual pathways are very few. This study aims to demonstrate the pattern of changes in retina and post retinal pathways in patients with acute OP poisoning using visual electrophysiological tests. This is an observational, cross-sectional study conducted at the Neurophysiology Unit, Teaching Hospital, Peradeniya, Sri Lanka. We tested 16 patients recovered from cholinergic phase, at least 24 h after deatropinization and within 8 weeks of OP ingestion. We assessed the functional integrity of the photoreceptors and ganglion cells of the macula by pattern electroretinography (PERG); RPE by electro-oculography (EOG); and post retinal pathways by pattern reversal visual evoked potentials (PR-VEP). Latencies and amplitudes of PR-VEP and PERG, light peak (LP), dark trough (DT) and Arden ratio of EOG were determined in patients and compared with 16 controls using the Mann-Whitney U test. Of the 16 OP-poisoned patients (median age of 37 ± IQR 20 years), six (37.5%)...Continue Reading

References

May 1, 1990·The Journal of Toxicological Sciences·H YoshikawaI Hara
Aug 1, 1986·Mechanisms of Ageing and Development·M L KatzW G Robison
Mar 1, 1985·Human Toxicology·U K MisraP K Ray
Apr 1, 1983·Environmental Research·H ImaiS Ishikawa
Mar 1, 1994·Journal of Applied Toxicology : JAT·B Dementi
Mar 1, 1994·Journal of Applied Toxicology : JAT·W K BoyesS Padilla
Nov 15, 2000·QJM : Monthly Journal of the Association of Physicians·M Eddleston
Jun 8, 2001·Progress in Retinal and Eye Research·G E Holder
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Michael EddlestonNick A Buckley
Jun 22, 2006·Food and Nutrition Bulletin·Renuka Jayatissa, R M Ranbanda
Aug 21, 2007·Lancet·Michael EddlestonAndrew H Dawson
Dec 25, 2007·BMC Public Health·David GunnellFlemming Konradsen
Jan 29, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Fu YuDecheng Bai
Nov 22, 2011·Annals of Emergency Medicine·Bishan N RajapakseNicholas A Buckley
Nov 29, 2011·Trends in Biochemical Sciences·Jane A GrasbyJohn A Tainer
Oct 18, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Michael BachSuresh Viswanathan
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jul 1, 2014·PloS One·Jagan Mohan JasnaNarayanasamy Angayarkanni
Mar 26, 2016·Oman Journal of Ophthalmology·Hang PhamAlex V Levin
Jul 23, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·J Vernon OdomUNKNOWN International Society for Clinical Electrophysiology of Vision
Jan 23, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Paul A ConstableUNKNOWN International Society for Clinical Electrophysiology of Vision
Feb 6, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Anthony G RobsonScott E Brodie
Nov 30, 2018·Annals of the New York Academy of Sciences·Renuka Jayatissa, Dulitha N Fernando

❮ Previous
Next ❯

Citations

Oct 21, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A K PannuR Vijayvergiya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved