Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer's disease

Metabolic Brain Disease
Jin-Zhi SongYong-He Zhang

Abstract

Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present study, we characterize the sleep/wake cycles and explore a potential mechanism underlying sleep disturbance in a rat model of sAD induced via intracerebroventricular (icv) injection of streptozotocin (STZ). STZ-icv rats exhibited progressive decreases in slow wave sleep (SWS) during the light phase and throughout the light/dark cycle beginning from 7 days after STZ-icv. Additionally, increased wakefulness and decreased rapid-eye-movement (REM) and non-REM (NREM) sleep were observed from 14 days after STZ-icv. Beginning on day 7, STZ-icv rats exhibited significant decreases in delta (0.5-4.0 Hz) power accompanied by increased power in the beta (12-30 Hz) and low gamma bands (30-50 Hz) during NREM sleep, resembling deficits in sleep quality observed in patients with AD. Immunohistochemical staining revealed a significant reduction in the ratio of c-Fos-positive GABAergic neurons in the parafacial zone (PZ) beginning f...Continue Reading

References

Dec 8, 2004·Neurobiology of Aging·Damien ColasNicole Sarda
Sep 4, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Khalid Iqbal, Inge Grundke-Iqbal
Sep 23, 2010·Journal of Alzheimer's Disease : JAD·Amar JyotiBettina Platt
Jan 26, 2011·Ageing Research Reviews·Sónia C CorreiaMark A Smith
Aug 23, 2011·Progress in Brain Research·E J W Van SomerenF H Lopes da Silva
May 4, 2012·Neuromolecular Medicine·Sarah M Rothman, Mark P Mattson
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christelle AnacletJun Lu
Mar 13, 2013·JAMA Neurology·Yo-El S JuDavid M Holtzman
Dec 25, 2013·Nature Reviews. Neurology·Yo-El S JuDavid M Holtzman
May 23, 2014·Sleep Medicine Reviews·Laure Peter-DerexBernard Croisile
Jun 8, 2014·Physiology & Behavior·F SchneiderK G Reymann
Aug 19, 2014·Nature Neuroscience·Christelle AnacletPatrick M Fuller
Nov 19, 2014·Neurodegenerative Disease Management·Miranda M LimDavid M Holtzman
Mar 15, 2015·Experimental & Molecular Medicine·Erik S MusiekDavid M Holtzman
Nov 23, 2015·The International Journal of Neuropsychopharmacology·Bin YuYong-He Zhang
Feb 3, 2016·Nature and Science of Sleep·Elena Urrestarazu, Jorge Iriarte
Feb 22, 2017·Neurobiology of Sleep and Circadian Rhythms·Jerrah HolthDavid M Holtzman
Jun 4, 2017·Current Opinion in Neurobiology·Clifford B Saper, Patrick M Fuller

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