Abstract
Previous studies had established that transforming growth factor-beta1 (TGF-beta1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial transitional cell carcinoma (TCC). In consistent with previously reported findings, the plasma TGF-beta1 concentration is also elevated in patients with superficial TCC. In vitro, the cytotoxic function of NK cells was impaired by the presence of TGF-beta1. Hence, our data suggested elevated concentration of serum TGF-beta1 in loss of NK cytotoxicity in superficial TCC patients, implicating altered innate immunity may correlate with the incidence of TCC.
References
Jun 24, 1996·Cancer Letters·C FortisM Braga
Sep 1, 1996·The Journal of Urology·I E EderH Klocker
Apr 20, 1999·Human Pathology·V IzadifarD K Chopin
Apr 22, 1999·Cancer Letters·S FujiedaH Saito
Jun 5, 1999·Journal of Immunological Methods·J E GoldbergC Clayberger
Jul 27, 2001·Immunology Letters·E DerbyA Malyguine
Mar 22, 2002·Nature Reviews. Immunology·A Cerwenka, L L Lanier
May 7, 2002·Urology·Muh-Hwa YangPo-Min Chen
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·D J GordonA R Taylor
Jul 10, 2004·Blood·Christophe BorgLaurence Zitvogel
Aug 4, 2004·The Journal of Experimental Medicine·Francesca GranucciPaola Ricciardi-Castagnoli
Mar 2, 2005·Cancer Letters·Hiroyuki NakamuraJun Miyoshi
Apr 27, 2005·Nature Immunology·Yasmina LaouarRichard A Flavell
Sep 8, 2005·BJU International·Thomas H TottermanMagnus Essand
Nov 16, 2005·Cancer Cell·Dori A Thomas, Joan Massagué
Aug 9, 2006·Seminars in Cancer Biology·Tal I ArnonOfer Mandelboim
Oct 26, 2006·Nature Reviews. Immunology·Gavin P DunnRobert D Schreiber
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Dec 13, 2006·The Journal of Urology·Angelica LoskogThomas H Tötterman
May 29, 2007·World Journal of Urology·Cristiane Murta-NascimentoNúria Malats
Apr 22, 2008·Cancer Letters·Hannelore DenysOlivier De Wever
May 15, 2008·Cancer Letters·Tzong-Tyng HungPamela J Russell
Sep 2, 2008·Cancer Letters·Ching-Yi LinRea-Min Chu
Dec 6, 2008·Scandinavian Journal of Immunology·F MilanoK K Krishnadath
Citations
Nov 14, 2013·PloS One·Kyo Chul KooSung Joon Hong
Mar 1, 2012·Journal of Gastroenterology·Kuo-Chih TsengShu-Fen Wu
Dec 15, 2015·Wiener klinische Wochenschrift·Kristian KrpinaNives Jonjić
Feb 28, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kuo-Chih TsengShu-Fen Wu
Dec 18, 2019·Cells·Joanna BoguslawskaAgnieszka Piekielko-Witkowska