Dysfunction of Nrf2-ARE Signaling Pathway: Potential Pathogenesis in the Development of Neurocognitive Impairment in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome

Oxidative Medicine and Cellular Longevity
Li ZhouGuiqian Liu

Abstract

The present study investigated the nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response element (ARE) signaling pathway in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome (OSAHS). Their correlation with neurocognitive impairment metrics was investigated to explore potential pathogenesis in OSAHS. Forty-eight patients with OSAHS and 28 controls underwent testing with the Epworth Sleep Scale (ESS), MATRICS Consensus Cognitive Battery (MCCB), Stroop Color and Word Test, polysomnography (PSG), and measurements of the concentration of plasma superoxide dismutase (SOD) and thioredoxin (Trx). Further, 20 pairs of matched patients with OSAHS and controls were selected for measurement of the expression (protein and mRNA) of Nrf2 and of its downstream antioxidase, heme oxygenase-1 (HO-1), in peripheral mononuclear cells (PBMCs). Finally, correlations between neurocognitive impairment and the above metrics were analyzed. Expression of Nrf2 and HO-1 mRNA and protein in the PBMCs, as well as plasma SOD and Trx levels, were significantly reduced in patients with OSAHS. After adjusting for education, sex, age, and smoking index, the expression of Nrf2-ARE signaling pathway proteins (or mRNA) was...Continue Reading

References

May 3, 1969·Nature·A Treisman, S Fearnley
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Barry W RowDavid Gozal
Jul 5, 2005·American Journal of Respiratory and Critical Care Medicine·Guanxia ZhanSigrid C Veasey
Jan 6, 2007·Journal of Neuropathology and Experimental Neurology·Chenere P RamseyKelly L Jordan-Sciutto
Jan 4, 2008·The American Journal of Psychiatry·Keith H NuechterleinStephen R Marder
Jan 27, 2011·Sleep & Breathing = Schlaf & Atmung·Kostas KatsoulisEfimia Daskalopoulou
May 3, 2011·Progress in Brain Research·Melinda L JacksonMaree Barnes
Dec 24, 2011·Schizophrenia Research·R Rodriguez-JimenezT Palomo
Jun 30, 2012·Recent Patents on CNS Drug Discovery·Gururaj Joshi, Jeffrey A Johnson
Sep 20, 2012·Current Opinion in Pulmonary Medicine·Madeleine Grigg-Damberger, Frank Ralls
Oct 3, 2012·Progress in Neurobiology·Meijuan ZhangFeng Zhang
Oct 4, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Iman A HakimH-H Sherry Chow
Dec 15, 2012·Cell Biochemistry and Biophysics·Qian HanJudith Choi Wo Mak
Dec 21, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Hyunjin Vincent KimYoungSoo Kim
Feb 1, 2013·The Clinical Neuropsychologist·Attilio RapisardaRichard S E Keefe
Jan 1, 2012·Dose-response : a Publication of International Hormesis Society·Weixia SunYaowen Fu
Aug 5, 2014·Annals of Internal Medicine·Amir QaseemUNKNOWN Clinical Guidelines Committee of the American College of Physicians
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Hans-Joachim EiseleRichard Schulz
Sep 19, 2015·Journal of Thoracic Disease·Karl A Franklin, Eva Lindberg
Jan 23, 2016·Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·W H DingJ J Shi
Oct 25, 2016·Oxidative Medicine and Cellular Longevity·Li ZhouRuoyun Ouyang
Dec 14, 2016·Journal of Cellular and Molecular Medicine·Melissa Christine KanderZhenguo Liu
Jan 25, 2017·The International Journal of Neuroscience·Yating PengRuoyun Ouyang
Apr 28, 2017·Frontiers in Psychology·Federica Scarpina, Sofia Tagini
Dec 24, 2017·Steroids·Mavis A TenkorangRebecca L Cunningham

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Citations

Jan 19, 2021·Journal of Healthcare Engineering·Fanlin ShenLili Dai
Jul 1, 2021·Cardiology and Therapy·Lyudmila Korostovtseva
Sep 4, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zongsheng TianMingxian Li

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Methods Mentioned

BETA
density gradient centrifugation
PCR
enzyme-linked immunosorbent assay
electrophoresis

Software Mentioned

SPSS
MATRICS

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