Dysfunction of transmission in the inner retina: incidence and clinical causes of negative electroretinogram.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Agnes B RennerMichael H Foerster

Abstract

Only limited data exist on the incidence of negative electroretinograms (ERG) in clinical practice. The purpose of this study is therefore to determine the incidence and clinical causes of a negative ERG in a tertiary care centre focused on inherited and acquired retinal degenerations. All ERGs recorded (in accordance with ISCEV standards) in our electrophysiological laboratory from 1992 to 2004 were retrospectively reviewed. The negative ERGs (criterion: ERG with b:a wave ratio<or=1 in the scotopic standard combined response in at least one eye) were analysed in the context of further clinical results. The photopic ON- and OFF-responses were recorded with long duration (200 ms) stimuli. A total of 1999 ERGs from 1644 patients were performed during the study period. 47/1644 patients (2.9%) presented with a negative ERG and were included in the study. Clinical diagnoses included inherited retinal dystrophies [X-linked congenital retinoschisis (XRS) (n=17), congenital stationary night blindness (CSNB) (n=6), retinitis pigmentosa (RP) (n=6), cone (-rod) dystrophy (n=5), choroideremia (n=1), Müller cell sheen dystrophy (MCSD) (n=1)] and acquired retinopathies (melanoma-associated retinopathy (MAR) (n=1), vigabatrin retinotoxicity (...Continue Reading

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Citations

Nov 22, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Claire S BarnesGeorge R Wilmot
Jan 17, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Johnstone M KimClaire S Barnes
Dec 19, 2006·Journal of Medical Genetics·Stephen K SikkinkDorothy Trump
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Jun 24, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarAnthony G Robson
Feb 15, 2011·European Journal of Ophthalmology·Takaaki HayashiHiroshi Tsuneoka
Jul 28, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Annie OhFreya M Mowat
Aug 10, 2021·BMJ Open Ophthalmology·Xiaofan JiangOmar A Mahroo
Jan 8, 2022·The Journal of International Medical Research·Weiming YanMeizhu Chen

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