Dysfunction of various organelles provokes multiple cell death after quantum dot exposure

International Journal of Nanomedicine
Yan Wang, Meng Tang

Abstract

Quantum dots (QDs) are different from the materials with the micrometer scale. Owing to the superiority in fluorescence and optical stability, QDs act as possible diagnostic and therapeutic tools for application in biomedical field. However, potential threats of QDs to human health hamper their wide utilization in life sciences. It has been reported that oxidative stress and inflammation are involved in toxicity caused by QDs. Recently, accumulating research unveiled that disturbance of subcellular structures plays a magnificent role in cytotoxicity of QDs. Diverse organelles would collapse during QD treatment, including DNA damage, endoplasmic reticulum stress, mitochondrial dysfunction and lysosomal rupture. Different forms of cellular end points on the basis of recent research have been concluded. Apart from apoptosis and autophagy, a new form of cell death termed pyroptosis, which is finely orchestrated by inflammasome complex and gasdermin family with secretion of interleukin-1 beta and interleukin-18, was also summarized. Finally, several potential cellular signaling pathways were also listed. Activation of Toll-like receptor-4/myeloid differentiation primary response 88, nuclear factor kappa-light-chain-enhancer of activ...Continue Reading

Citations

May 23, 2019·Archives of Pharmacal Research·Yeonsun JinSung Hoon Lee
Jul 12, 2019·Journal of Applied Toxicology : JAT·Na Liu, Meng Tang
Jan 8, 2020·International Journal of Environmental Research and Public Health·Beatriz MatosMário S Diniz
Jul 22, 2018·Frontiers in Neuroscience·Lorena F FernandesFrédéric Frézard
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chayma El KhamlichiSéverine Morisset-Lopez
May 10, 2020·International Journal of Molecular Sciences·Samuela CataldiElisabetta Albi
Oct 10, 2020·Journal of Applied Toxicology : JAT·Xiaoquan Huang, Meng Tang
Aug 21, 2020·The Science of the Total Environment·Xue LiangMeng Tang
May 6, 2021·International Journal of Molecular Sciences·Yung-Li WangHui-Wen Chiu
Oct 7, 2020·Ecotoxicology and Environmental Safety·Zhiwen YangGuimiao Lin
Jun 3, 2021·International Journal of Environmental Research and Public Health·Lishi ZhongTianshu Wu
Feb 14, 2020·The Science of the Total Environment·Yan Wang, Meng Tang

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Methods Mentioned

BETA
electrophoresis
glycosylation
ubiquitination

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