Dysfunctional Brain Networking among Autonomic Regulatory Structures in Temporal Lobe Epilepsy Patients at High Risk of Sudden Unexpected Death in Epilepsy.

Frontiers in Neurology
Luke A AllenBeate Diehl

Abstract

Sudden unexpected death in epilepsy (SUDEP) is common among young people with epilepsy. Individuals who are at high risk of SUDEP exhibit regional brain structural and functional connectivity (FC) alterations compared with low-risk patients. However, less is known about network-based FC differences among critical cortical and subcortical autonomic regulatory brain structures in temporal lobe epilepsy (TLE) patients at high risk of SUDEP. 32 TLE patients were risk-stratified according to the following clinical criteria: age of epilepsy onset, duration of epilepsy, frequency of generalized tonic-clonic seizures, and presence of nocturnal seizures, resulting in 14 high-risk and 18 low-risk cases. Resting-state functional magnetic resonance imaging (rs-fMRI) signal time courses were extracted from 11 bilateral cortical and subcortical brain regions involved in autonomic and other regulatory processes. After computing all pairwise correlations, FC matrices were analyzed using the network-based statistic. FC strength among the 11 brain regions was compared between the high- and low-risk patients. Increases and decreases in FC were sought, using high-risk > low-risk and low-risk > high-risk contrasts (with covariates age, gender, late...Continue Reading

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Citations

Jan 30, 2019·Current Opinion in Neurology·Philippe RyvlinSamden D Lhatoo
Dec 31, 2019·Epilepsy Currents·Dario J Englot
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May 1, 2021·Journal of Personalized Medicine·Shu-Fang ChenYao-Chung Chuang
Aug 20, 2021·Autonomic Neuroscience : Basic & Clinical·Smriti PatodiaMaria Thom
Oct 31, 2021·Nature Reviews. Neurology·Roland D ThijsRainer Surges
Oct 16, 2021·Neurology·Shobi SivathambooUNKNOWN MS-BioS Study Group

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Software Mentioned

DARTEL
Network Based Statistic [ NBS
DPARSFA
MORTEMUS
SPM12
MATLAB
REST
CompCor

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