Aug 23, 2017

Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease

Molecular and Cellular Biochemistry
Rai Ajit K Srivastava

Abstract

Coronary artery disease, the leading cause of death in the developed and developing countries, is prevalent in diabetes mellitus with 68% cardiovascular disease (CVD)-related mortality. Epidemiological studies suggested inverse correlation between HDL and CVD occurrence. Therefore, low HDL concentration observed in diabetic patients compared to non-diabetic individuals was thought to be one of the primary causes of increased risks of CVD. Efforts to raise HDL level via CETP inhibitors, Torcetrapib and Dalcetrapib, turned out to be disappointing in outcome studies despite substantial increases in HDL-C, suggesting that factors beyond HDL concentration may be responsible for the increased risks of CVD. Therefore, recent studies have focused more on HDL function than on HDL levels. The metabolic environment in diabetes mellitus condition such as hyperglycemia-induced advanced glycation end products, oxidative stress, and inflammation promote HDL dysfunction leading to greater risks of CVD. This review discusses dysfunctional HDL as one of the mechanisms of increased CVD risks in diabetes mellitus through adversely affecting components that support HDL function in cholesterol efflux and LDL oxidation. The dampening of reverse chole...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Study
Pathogenic Aspects
Pathogenesis
CETP protein, human
Coronary Artery Disease
Reverse Cholesterol Transport
Environment
Cessation of Life
Inhibitors

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