Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases

Current HIV/AIDS Reports
Tiffany R ButterfieldJoshua J Anzinger

Abstract

An increasing body of evidence indicates that persons living with HIV (PLWH) display dysfunctional immunometabolism. Here, we provide an updated review of this topic and its relationship to HIV-associated immune stimuli and age-related disease. HIV infection alters immunometabolism by increasing reliance on aerobic glycolysis for energy and productive infection and repurposing oxidative phosphorylation machinery for immune cell proliferation and survival. Recent studies in PLWH with diabetes mellitus or cardiovascular disease have identified an association with elevated T cell and monocyte glucose metabolism, respectively. Immunometabolic dysfunction has also been observed in PLWH in frailty and additional studies suggest a role for immunometabolism in non-AIDS defining cancers and neurocognitive disease. There is a plethora of HIV-associated immune stimuli that could drive immunometabolic dysfunction and age-related disease in PLWH, but studies directly examining their relationship are lacking. Immunometabolic dysfunction is characteristic of HIV infection and is a potential link between HIV-associated stimuli and age-related comorbidities.

References

Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D SäemannG J Zlabinger
Feb 18, 2005·The Journal of Infectious Diseases·B SetzerUlrich A Walker
Jan 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy F CrumUNKNOWN Triservice AIDS Clinical Consortium
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric A EngelsRichard D Moore
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory D KirkEric A Engels
Nov 15, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Loic DesquilbetUNKNOWN Multicenter AIDS Cohort Study
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah PalmerMartin S King
Oct 24, 2008·PLoS Medicine·Lewis H KullerUNKNOWN INSIGHT SMART Study Group
Jun 18, 2009·Current Opinion in Infectious Diseases·Justin StebbingMark Bower
Sep 29, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Silvia BaroncelliLucia Palmisano
Apr 13, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Antiretroviral Therapy Cohort Collaboration
Apr 23, 2010·HIV Medicine·S JandaJ Swiston
Jan 12, 2011·The Journal of Infectious Diseases·Robert C KaplanSteven G Deeks
Jan 15, 2011·Nature Reviews. Immunology·Marc Y Donath, Steven E Shoelson
May 20, 2011·Nature·Peter LibbyGöran K Hansson
Oct 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Giovanni GuaraldiFrank Palella
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Séverine Loisel-MeyerNaomi Taylor
Apr 12, 2012·The Journal of Infectious Diseases·Christina M ParrinelloRobert C Kaplan
Oct 2, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David J KimJames H Willig
Jan 9, 2013·Clinical Microbiology Reviews·Giulia MarchettiGuido Silvestri
Jan 15, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael J VinikoorJoseph J Eron
Mar 19, 2013·PloS One·Magdalina KalinowskaScott F Sieg
Apr 23, 2013·Immunity·Erika L Pearce, Edward J Pearce
Jul 12, 2013·Science Translational Medicine·Ivan Vujkovic-CvijinJoseph M McCune

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Citations

Sep 17, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Aldrey Nascimento CostaMarcus Vinicius Guimarães de Lacerda
Jan 4, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lauren F CollinsIghovwerha Ofotokun

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