Dysfunctional LAD-1 neutrophils and colitis

Gastroenterology
Gulbu UzelSteven M Holland

Abstract

Leukocyte adhesion deficiency 1 (LAD-1) is characterized by absent or dysfunctional beta2 integrin (CD18), leading to defective chemotaxis, adherence, phagocytosis, and bacterial killing. Colitis, except for rare intestinal necrotizing events, is not a well-recognized feature of this immunodeficiency. A case of nonspecific colitis clinically resembling Crohn's disease in a patient with the severe form of LAD-1 (0.5% < CD18) has been previously reported. We describe an adult patient with the moderate form of LAD-1 and chronic colitis characterized by extensive inflammation and ulceration of the right colon and terminal ileum, leading to adhesions and strictures. The chronic colitis described in this article associated with the dysfunctional neutrophils of LAD-1 represents a distinct pathology from the commonly encountered forms of inflammatory bowel disease (IBD). The existence of active IBD in the presence of dysfunctional CD18/CD11(a-b) intercellular adhesion molecules (ICAM-1) interaction is relevant to the proposed targeting of ICAM-1 for the treatment of Crohn's disease.

Citations

Jun 14, 2014·Current Opinion in Organ Transplantation·Nicholas A Zwang, Laurence A Turka
Oct 29, 2014·Nature Communications·Vicky Louise MorrisonSusanna Carola Fagerholm
May 14, 2018·Clinical Reviews in Allergy & Immunology·Stella HartonoNicholas L Rider
Feb 26, 2020·International Journal of Molecular Sciences·Monika BednarczykMatthias Bros
Jul 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ritu Sarin, Clara Abraham
Aug 20, 2014·Journal of Clinical Immunology·Manuela MarsiliLuciana Breda
Aug 30, 2016·Journal of Pediatric Hematology/oncology·Chana L GlasserNancy S Green
Apr 19, 2008·Inflammatory Bowel Diseases·Farooq Z RahmanAnthony W Segal
Nov 26, 2015·World Journal of Gastroenterology : WJG·Anna Monica BiancoAlberto Tommasini
Jan 17, 2002·Current Treatment Options in Gastroenterology·Robert P. McCabe
Dec 17, 2008·Current Opinion in Rheumatology·Ramona GoyalRichard M Siegel
Dec 15, 2016·FEMS Microbiology Reviews·Helene BuvelotKarl-Heinz Krause
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marissa MarskiClara Abraham
Jun 16, 2010·Journal of Clinical Immunology·Nima ParvanehAsghar Aghamohammadi
Apr 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Nikhil ThaparPeter J Milla
Mar 29, 2014·Science Translational Medicine·Niki M MoutsopoulosGeorge Hajishengallis
Apr 23, 2010·Journal of Pediatric Gastroenterology and Nutrition·Ajay Kumar JainNina Tatevian
Oct 6, 2012·The Journal of Allergy and Clinical Immunology·Jennifer W Leiding, Steven M Holland
Jul 25, 2014·Gastroenterology·Holm H UhligUNKNOWN COLORS in IBD Study Group and NEOPICS

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