Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production.

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Brian J SkaggsMaureen A McMahon

Abstract

Accelerated atherosclerosis is a major co-morbid condition in autoimmune diseases. Monocytes are the main immune cell involved in atherosclerosis initiation. We hypothesized that dysfunctional, pro-inflammatory HDL (piHDL), which occurs in approximately half of SLE patients, might directly influence monocyte gene expression and function. SLE subjects were stratified into three groups: 1) carotid artery plaque+piHDL+,2) plaque-piHDL+,and 3) plaque-piHDL- (n=18/group). PDGFRβ was upregulated in primary monocytes from plaque+piHDL+patients and in THP-1 cells acutely treated in vitro with piHDL compared to normal HDL. THP-1 chemotaxis was enhanced after treatment with piHDL versus normal HDL. Abnormal migration was restored to normal levels by treatment with imatinib or an apoJ mimetic peptide. Increased piHDL-mediated TNFα protein levels were reduced with both inhibitors. Dysfunctional piHDL directly influences expression of a small number of transcripts and proteins, and piHDL inhibition through reducing piHDL oxidation or blocking PDGFRβ kinase activity restored normal monocyte chemotaxis.

References

Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Nov 1, 1992·The American Journal of Medicine·M PetriM C Hochberg
Apr 1, 1982·The Journal of Clinical Investigation·T F DeuelG L Griffin
Nov 24, 1999·Lupus·M Y KimR E Shore
Jun 6, 2000·The Journal of Infectious Diseases·W KhovidhunkitC Grunfeld
Jul 6, 2000·Lupus·D D GladmanV T Farewell
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana J KaplanBruce C Richardson
Dec 19, 2003·The New England Journal of Medicine·Mary J RomanJane E Salmon
Dec 19, 2003·The New England Journal of Medicine·Yu AsanumaC Michael Stein
Apr 3, 2004·Journal of Lipid Research·Mohamad NavabAlan M Fogelman
Apr 13, 2004·The Journal of Biological Chemistry·Geeta DattaG M Anantharamaiah
Jun 23, 2004·Cytokine & Growth Factor Reviews·Elaine W Raines
Nov 6, 2004·Current Opinion in Lipidology·Mohamad NavabAlan M Fogelman
Jun 18, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Mohamad NavabAlan M Fogelman
Jun 25, 2005·Circulation Research·Gary F Lewis, Daniel J Rader
Sep 15, 2005·Atherosclerosis·Gianna FerrettiGiovanna Curatola
Dec 20, 2005·Micron : the International Research and Review Journal for Microscopy·Yuri V Bobryshev
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael F DennyMariana J Kaplan
Mar 3, 2007·The Journal of Clinical Investigation·Tomas VaisarJay W Heinecke
Apr 21, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Emmanuel L GautierPhilippe Lesnik
Aug 31, 2007·Kidney International·K Kalantar-ZadehM Navab
Sep 25, 2007·Journal of Lipid Research·Sander I van LeuvenDaan W Hommes
Mar 8, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zhongjie MaRobert A Eisenberg
Jul 16, 2008·Journal of Lipid Research·Brian J Van LentenAlan M Fogelman
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Feb 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Eduard Shantsila, Gregory Y H Lip
Jul 15, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Mariana J Kaplan
Sep 17, 2009·JAMA : the Journal of the American Medical Association·Marietta CharakidaJohn E Deanfield
Apr 11, 2015·Lupus Science & Medicine·Meggan MackayDavid Eidelberg

❮ Previous
Next ❯

Citations

Jun 8, 2012·Nature Medicine·Zheng Liu, Anne Davidson
May 4, 2011·Current Opinion in Lipidology·Bela F AsztalosErnst J Schaefer
Jun 27, 2012·Current Opinion in Lipidology·Handrean SoranPaul N Durrington
Sep 25, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine QuinlanKjell Tullus
Feb 21, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert Terkeltaub
Jul 28, 2019·Arthritis & Rheumatology·Sang Yeop KimAnna Schwendeman
Feb 18, 2011·Current Opinion in Infectious Diseases·Michael J Haas, Arshag D Mooradian
Mar 24, 2011·Expert Review of Clinical Immunology·Maureen McMahonBrian J Skaggs
Feb 10, 2011·Nature Reviews. Cardiology·Mohamad NavabAlan M Fogelman
May 17, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Veer Bala GuptaUNKNOWN AIBL Research Group
Jan 29, 2021·Scientific Reports·Floran BegueOlivier Meilhac

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.