Dysfunctional Striatal Systems in Treatment-Resistant Schizophrenia

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Thomas P WhiteSukhwinder S Shergill

Abstract

The prevalence of treatment-resistant schizophrenia points to a discrete illness subtype, but to date its pathophysiologic characteristics are undetermined. Information transfer from ventral to dorsal striatum depends on both striato-cortico-striatal and striato-nigro-striatal subcircuits, yet although the functional integrity of the former appears to track improvement of positive symptoms of schizophrenia, the latter have received little experimental attention in relation to the illness. Here, in a sample of individuals with schizophrenia stratified by treatment resistance and matched controls, functional pathways involving four foci along the striatal axis were assessed to test the hypothesis that treatment-resistant and non-refractory patients would exhibit contrasting patterns of resting striatal connectivity. Compared with non-refractory patients, treatment-resistant individuals exhibited reduced connectivity between ventral striatum and substantia nigra. Furthermore, disturbance to corticostriatal connectivity was more pervasive in treatment-resistant individuals. The occurrence of a more distributed pattern of abnormality may contribute to the failure of medication to treat symptoms in these individuals. This work strong...Continue Reading

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Citations

Nov 13, 2017·European Archives of Psychiatry and Clinical Neuroscience·Mingli LiTao Li
Jul 30, 2019·The American Journal of Psychiatry·Peter KochunovL Elliot Hong
Jul 20, 2020·European Archives of Psychiatry and Clinical Neuroscience·Roberto LimongiLena Palaniyappan
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