PMID: 6162859Mar 1, 1981Paper

Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy

The Journal of Clinical Investigation
A DurandyC Griscelli

Abstract

Lymphocytes obtained from nonimmuno deficient children treated with commercially available preparations of gammaglobulin failed to proliferate and to mature into plasma cells in vitro after stimulation with pokeweed mitogen. The influence of the treatment on lymphocyte functions varied according to the cell population considered. A T helper cell activity was detected in these patients but only in the cell subset bearing receptors for IgG after irradiation. T lymphocytes exerted a suppressive effect that disappeared after irradiation or incubation at 37 degrees C. The suppressive cells were found among E rosette-forming cells depleted of leukocytes bearing receptors for IgG. Their suppressive effect was expressed only in the presence of normal radioresistant T lymphocytes that did not bear Fc receptors for IgG. Similar dysfunctions could be induced in vitro by incubation of normal T and B lymphocytes with gammaglobulin preparations. Because F(ab)'2 fragments or deaggregated preparations of gammaglobulin failed to activate T suppressor lymphocytes, this activation was likely triggered by attachment of Fc portion of denatured IgG to the corresponding membrane receptor. This activation step was prostaglandin E(2)-dependent, suggest...Continue Reading

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Citations

Oct 1, 1983·Journal of Clinical Immunology·J S Goodwin, J Ceuppens
May 1, 1991·Journal of Clinical Immunology·N KondoT Orii
Jul 1, 1995·Journal of Clinical Immunology·H Haas, M Schlaak
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Dec 1, 1988·Journal of Clinical Pathology·H I Atrah, R J Davidson
Feb 1, 1987·The Journal of Clinical Investigation·D Y LeungR S Geha
Apr 15, 2005·Molecular Immunology·Réal LemieuxSonia Néron
Jan 1, 1986·Vox Sanguinis·C Cunningham-Rundles
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May 1, 1991·The Journal of Allergy and Clinical Immunology·B D Mazer, E W Gelfand
Aug 1, 1984·Scandinavian Journal of Immunology· Lê Thi Bich-Thuy, J P Revillard
Aug 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·R I Schiff
Jan 1, 1987·Clinical and Laboratory Haematology·R M Minchinton, K McGrath

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