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Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

Science

Jan 11, 2003

Davide RuggeroPier Paolo Pandolfi

Abstract

Mutations in DKC1 cause dyskeratosis congenita (DC), a disease characterized by premature aging and increased tumor susceptibility. The DKC1 protein binds to the box H + ACA small nucleolar RNAs and the RNA component of telomerase. Here we show that hypomorphic Dkc1 mutant (Dkc1m) mice ...read more

Mentioned in this Paper

Fluorescent in Situ Hybridization
Colony-Forming Units, Hematopoietic
Apoptosis, Intrinsic Pathway
Cell Cycle Proteins
Telomere Shortening
Telomerase Catalytic Subunit
Transcription Initiation
Ribosomal RNA
X-Linked Dyskeratosis Congenita
Nucleolar
142
1
Paper Details
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Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 9, 2004
Yuko MochizukiPhilip J Mason
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Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

Science

Jan 11, 2003

Davide RuggeroPier Paolo Pandolfi

PMID: 12522253

DOI: 10.1126/science.1079447

Abstract

Mutations in DKC1 cause dyskeratosis congenita (DC), a disease characterized by premature aging and increased tumor susceptibility. The DKC1 protein binds to the box H + ACA small nucleolar RNAs and the RNA component of telomerase. Here we show that hypomorphic Dkc1 mutant (Dkc1m) mice ...read more

Mentioned in this Paper

Fluorescent in Situ Hybridization
Colony-Forming Units, Hematopoietic
Apoptosis, Intrinsic Pathway
Cell Cycle Proteins
Telomere Shortening
Telomerase Catalytic Subunit
Transcription Initiation
Ribosomal RNA
X-Linked Dyskeratosis Congenita
Nucleolar
142
1

Similar Papers Found In These Feeds

Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Telomeres in Cancer (Keystone)

Telomeres protect our genetic data and are found at the end of chromosomes. When a cell divides, telomeres become shorter. This process has been associated with the development of cancer. Here is the latest research on telomeres in cancer.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 9, 2004
Yuko MochizukiPhilip J Mason
Paper Details
References
  • References
  • Citations211
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations211
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