Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report

Rinshō shinkeigaku = Clinical neurology
Soutarou TaguchiManabu Doyu

Abstract

Non-physiological, excessive dopaminergic stimulation can cause dyskinesia-hyperpyrexia syndrome (DHS), which was initially reported by Gil-Navarro and Grandas in 2010. A 70-years-old woman with a 13-years history of Parkinson's disease (PD) was hospitalized due to difficulty walking, despite being treated with levodopa/carbidopa (600 mg/day), immediate-release pramipexole (3 mg/day), and selegiline (5 mg/day). Immediate-release pramipexole was changed to extended-release pramipexole without changing the dose or levodopa equivalent dose (LED). The patient's adherence to drugs was good. The parkinsonism gradually improved and the patient was discharged. One month later, the patient developed severe generalized athetotic dyskinesia with visual hallucinations and hyperpyrexia that lasted for a week, and she was readmitted to hospital. On admission, the patient was conscious but slightly disoriented. Body temperature was 40.3°C with hyperhidrosis. Leukocyte count in the peripheral blood was 1.78×10(4)/ml and serum creatine kinase was >3×10(4) U/l. Chest survey, whole-body computed tomography, and cranial magnetic resonance imaging showed no abnormalities. The patient was diagnosed with DHS and treated by tapering the oral administr...Continue Reading

References

Apr 6, 2000·The American Journal of Emergency Medicine·S A Factor, E S Molho
Aug 21, 2008·Neurocritical Care·Edward J NewmanPeter G E Kennedy
Aug 20, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Silvia Gil-Navarro, Francisco Grandas
Apr 19, 2011·Journal of Neurology·Chul Hyoung Lyoo, Myung Sik Lee

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Citations

Jun 26, 2015·Current Opinion in Neurology·Renato P MunhozStewart A Factor
Apr 6, 2016·Clinical Neuropharmacology·Jaime Herreros-Rodriguez, Álvaro Sánchez-Ferro
Jan 5, 2017·Parkinsonism & Related Disorders·Fernando Acebrón Sánchez-HerreraJose Luis López-Sendón Moreno
Jul 15, 2017·Journal of Movement Disorders·Min Seok BaekChul Hyoung Lyoo
Mar 28, 2017·Therapeutic Advances in Neurological Disorders·Johan Virhammar, Dag Nyholm
Dec 6, 2018·Movement Disorders Clinical Practice·Marianna SarchiotoGiovanni Cossu
Apr 8, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Miao WangZhenfu Wang

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