Abstract
While dyslipidemia importantly contributes to increased cardiovascular disease risk among patients on antiretroviral therapy (ART), data on lipid patterns among African adults on ART are limited. We describe the prevalence of lipid abnormalities and associated factors in two HIV clinics in Malawi. We conducted a cross-sectional study in 2014 and enrolled adult patients at a rural and an urban HIV clinic in Zomba district, Malawi. We recorded patient characteristics, CVD risk factors and anthropometric measurements, using the WHO STEPS validated instrument. Non-fasting samples were taken for determination of total cholesterol (TC), triglyceride (TG) and HDL-cholesterol (HDL-c) levels. Logistic regression analysis was used to determine factors associated with elevated TC and elevated TC/HDL-c ratio. 554 patients were enrolled, 50% at the rural HIV clinic, 72.7% were female, the median (IQR) age was 42 years (36-50); 97.3% were on ART, 84.4% on tenofovir/lamivudine/efavirenz, 17.5% were overweight/obese and 27.8%% had elevated waist/hip ratio. 15.5% had elevated TC, 15.9% reduced HDL-c, 28.7% had elevated TG and 3.8% had elevated TC/HDL-c ratio. Lipid abnormalities were similar in rural and urban patients. Women had significantly ...Continue Reading
References
Aug 4, 2007·American Journal of Preventive Medicine·Myles Dean ConnorCharles P Warlow
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jun 6, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F BarziR Huxley
Jul 14, 2010·Tropical Medicine & International Health : TM & IH·Adrienne K ChanMonique van Lettow
Mar 2, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Enju LiuWafaie Fawzi
Aug 29, 2013·HIV Medicine·C N MenezesI Sanne
Jan 11, 2014·European Heart Journal·Lars G Hemkens, Heiner C Bucher
Jan 15, 2014·International Journal of Epidemiology·David G DillonUNKNOWN African Partnership for Chronic Disease Research (APCDR)
Sep 4, 2014·BMC Public Health·Gibson B KagarukiSayoki G Mfinanga
Dec 20, 2015·AIDS Patient Care and STDs·Daniel MuyanjaMark J Siedner
Jan 15, 2016·Medicine·Phumla Zuleika SinxadiGary Maartens
Feb 14, 2016·The Lancet. Diabetes & Endocrinology·Eric NouSteven K Grinspoon
Apr 29, 2016·European Heart Journal·Børge G NordestgaardUNKNOWN European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) join
Nov 16, 2016·Bulletin of the World Health Organization·Andreas JahnFrank Chimbwandira
Dec 14, 2016·BMC Public Health·Oscar H DivalaJoep J van Oosterhout
Mar 24, 2017·HIV Medicine·L JamiesonM P Fox
Jun 11, 2017·Lipids in Health and Disease·Anne NjorogeCarey Farquhar
Aug 12, 2017·Lipids in Health and Disease·Steve Raoul Ngongang NoumegniEugene Sobngwi
Citations
Oct 1, 2019·BMJ Global Health·Ana Luiza G SoaresAmelia Crampin
Jan 18, 2019·PloS One·Alemayehu AmberbirJoep J van Oosterhout
Jun 1, 2019·PloS One·Qing WuJie Gu
Jul 10, 2020·PloS One·Irene KatoKisali Pallangyo
Sep 4, 2019·African Journal of Primary Health Care & Family Medicine·Rumbidzai ChiresheRudo Nyamakura
Feb 10, 2021·PloS One·Gebremedhin GebreegziabiherDessalegn Tamiru
Feb 17, 2021·PloS One·Benson M HamooyaDouglas C Heimburger
Mar 2, 2021·HIV/AIDS : Research and Palliative Care·Abebe Muche BeleteAlemu Adela Tefera
Apr 28, 2021·PloS One·Temesgen FisehaAngesom Gebreweld
Aug 7, 2021·Metabolism Open·Zemene Demelash KifleBiruk Bayleyegn