Dyslipidemia as a risk factor for coronary disease in patients with diabetes.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
A J Garber

Abstract

To highlight the frequency of lipid abnormalities in patients with diabetes and the need for appropriate treatment strategies for coronary disease. The epidemiologic features of coronary artery disease in the diabetic population are reviewed, and the pathogenesis of atherosclerotic disease is discussed. Various risk factors for predicting coronary artery disease and guidelines for therapeutic intervention are presented. The American Diabetes Association has estimated that 60% of all adults will die of coronary artery disease and that 80% of patients with diabetes will ultimately have atherosclerosis. The accelerated rate of atherosclerosis in patients with diabetes may be attributable to several factors, including hyperglycemia and insulin resistance. Abnormalities in lipid metabolism have a major role in the development of coronary disease. Because the National Cholesterol Education Program guidelines for treatment were established for less complicated hyperlipidemias, The American Diabetes Association recommends more aggressive lipid-lowering therapy at a lower level of low-density lipoproteins (130 mg/dL or 3.36 mmol/L) to produce an equivalent reduction in risk of coronary disease in patients with diabetes. In patients with...Continue Reading

Citations

Jul 1, 1997·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R H Knopp

❮ Previous
Next ❯

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.