Dyslipidemia in HIV Infected Children Receiving Highly Active Antiretroviral Therapy

Indian Journal of Pediatrics
Anirban MandalRakesh Lodha

Abstract

To assess the prevalence of dyslipidemia and lipodystrophy in Indian children receiving non-nucleoside reverse transcriptase inhibitor (NNRTI) based highly active antiretroviral therapy (HAART) and to determine the associated risk factors for the same. The present cross-sectional study was conducted at a Pediatric Clinic of a tertiary care teaching center in India, from May 2011 through December 2012. HIV infected children aged 5-15 y were enrolled if they did not have any severe disease or hospital admission within last 3 mo or receive any medications known to affect the lipid profile. Eighty-one children were on highly active antiretroviral therapy (HAART) for at least 6 mo and 16 were receiving no antiretroviral therapy (ART). Participants' sociodemographic, nutritional, clinical, and laboratory data were recorded in addition to anthropometry and evidence of lipodystrophy. Fasting lipid profile, apolipoprotein A1 and B levels were done for all the children. Among the children on highly active antiretroviral therapy (HAART), 38.3 % had dyslipidemia and 80.2 % had lipodystrophy, while 25 % antiretroviral therapy (ART) naïve HIV infected children had dyslipidemia. No clinically significant risk factors could be identified that ...Continue Reading

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Citations

Feb 7, 2016·Indian Journal of Pediatrics·Mamatha M Lala, Rashid H Merchant
Apr 22, 2017·The Journal of Endocrinology·Caroline E Geisler, Benjamin J Renquist
Mar 31, 2019·Journal of Clinical Medicine·Birkneh Tilahun TadesseEleni Aklillu
Dec 1, 2017·The Pediatric Infectious Disease Journal·C PadmapriyadarsiniSoumya Swaminathan
Dec 4, 2021·Frontiers in Cellular and Infection Microbiology·Wilbert MbuyaMkunde Chachage

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