Dyslipidemias and Cardiovascular Prevention: Tailoring Treatment According to Lipid Phenotype

Current Cardiology Reports
Veronika SaninWolfgang Koenig

Abstract

This study aimed to present the current information on the genetic background of dyslipidemias and provide insights into the complex pathophysiological role of several plasma lipids/lipoproteins in the pathogenesis of atherosclerotic cardiovascular disease. Furthermore, we aim to summarize established therapies and describe the scientific rationale for the development of novel therapeutic strategies. Evidence from genetic studies suggests that besides lowering low-density lipoprotein cholesterol, pharmacological reduction of triglyceride-rich lipoproteins, or lipoprotein(a) will reduce risk for coronary heart disease. Dyslipidemia, in particular hypercholesterolemia, is a common clinical condition and represents an important determinant of atherosclerotic vascular disease. Treatment decisions are currently guided by the causative lipid phenotype and the presence of other risk factors suggesting a very high cardiovascular risk. Therefore, the identification of lipid disorders and the optimal combination of therapeutic strategies provide an outstanding opportunity for reducing the onset and burden of cardiovascular disease.

References

Aug 1, 1992·The American Journal of Clinical Nutrition·A M Dattilo, P M Kris-Etherton
Dec 1, 1986·Journal of the American College of Cardiology·P L CannerW Friedewald
Apr 22, 1993·The New England Journal of Medicine·D A HellerG E McClearn
Apr 3, 2001·Circulation·P Kris-EthertonUNKNOWN Nutrition Committee Population Science Committee and Clinical Science Committee of the American Heart Association
May 22, 2001·Science·J L Goldstein, M S Brown
Sep 19, 2002·British Journal of Clinical Pharmacology·Teddy KosoglouMelton B Affrime
Oct 9, 2002·Circulation·Thomas SudhopKlaus von Bergmann
May 6, 2003·Nature Genetics·Marianne AbifadelCatherine Boileau
Jun 19, 2003·The Journal of Clinical Investigation·Daniel J RaderHelen H Hobbs
Jun 5, 2004·Atherosclerosis·Fernando Civeira, UNKNOWN International Panel on Management of Familial Hypercholesterolemia
Jun 17, 2004·Circulation·Jean Davignon
Apr 28, 2005·International Journal of Clinical Practice·R Y A MukhtarJ P D Reckless
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Sep 4, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Angela A RivelleseGabriele Riccardi
Nov 7, 2007·The New England Journal of Medicine·Philip J BarterUNKNOWN ILLUMINATE Investigators
Jun 14, 2008·The American Journal of Cardiology·Vaijinath S Kamanna, Moti L Kashyap
Nov 21, 2008·Journal of Lipid Research·Jay D HortonHelen H Hobbs
Mar 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Kornelia KotsevaUNKNOWN EUROASPIRE Study Group
Jun 11, 2009·JAMA : the Journal of the American Medical Association·Pia R KamstrupBørge G Nordestgaard
Nov 12, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Dec 25, 2009·The New England Journal of Medicine·Robert ClarkeUNKNOWN PROCARDIS Consortium
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Qian Zhou, James K Liao
May 11, 2010·Lancet·UNKNOWN Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors CollaborationJohn Danesh
May 12, 2010·Journal of Clinical Pharmacy and Therapeutics·T-C WengS-H Tai
Jul 16, 2010·Current Opinion in Cell Biology·Frederick R Maxfield, Gerrit van Meer
Sep 3, 2010·The American Journal of Clinical Nutrition·Francesco SofiAlessandro Casini
Oct 23, 2010·European Heart Journal·Børge G NordestgaardUNKNOWN European Atherosclerosis Society Consensus Panel
Dec 24, 2010·European Heart Journal·Catherine McGorrianUNKNOWN INTERHEART Investigators
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Apr 20, 2011·Circulation·Michael MillerUNKNOWN Council on the Kidney in Cardiovascular Disease
Jun 28, 2011·The Journal of Clinical Investigation·Christian BeslerUlf Landmesser
Nov 17, 2011·The New England Journal of Medicine·William E BodenWilliam Weintraub
Nov 24, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Marie W LindholmTroels Koch
Mar 9, 2012·Atherosclerosis·Frederick J Raal, Raul D Santos

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