Dysmorphic erythrocytes are superior to hematuria for indicating non-diabetic renal disease in type 2 diabetics

Journal of Diabetes Investigation
Zhe-yi DongXiang-mei Chen

Abstract

There are sparse and limited studies on erythrocyte morphology in renal biopsy identifying nephropathic patients among type 2 diabetics. The present study sought to clarify the predictive value of dysmorphic erythrocytes in type 2 diabetics with non-diabetic renal disease and influences on hematuria. We examined 198 patients with type 2 diabetes who underwent kidney biopsies between 2012 and 2013. Hematuria was defined as >3 or >10 red blood cells per high-power field (RBCs/hpf) in urine sediment. If >80% of the erythrocytes were dysmorphic, glomerular hematuria was diagnosed. Clinical findings and predictive value of dysmorphic erythrocytes were compared between patients with hematuria (n = 19) and those without (n = 61). The potential risk factors for hematuria among diabetic nephropathy patients were also screened. There was a statistically significant difference between the diabetic nephropathy group and the non-diabetic renal disease group (6.6 vs 16.8%; P = 0.04) when the demarcation point of hematuria was 10 RBCs/hpf. When the definition of hematuria was based on an examination of urinary erythrocyte morphology, a marked difference was seen (3.3 vs 24.8%; P < 0.001). Glomerular hematuria showed high specificity and a pos...Continue Reading

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Citations

Jul 12, 2005·Clinics in Sports Medicine·Thomas S Weber
Oct 22, 2013·Journal of Bodywork and Movement Therapies·Lilian Chrystiane GiannasiLuis Vicente Franco de Oliveira
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Methods Mentioned

BETA
biopsy
biopsies
urine sediment

Software Mentioned

SPSS

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