Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis

BMC Nephrology
Luiz Derwal Salles JuniorMarcellus Henrique Loiola Ponte de Souza

Abstract

Dyspepsia is common among end-stage renal disease (ESRD) patients and its association with delayed gastric emptying is not well established. We assessed the association of dyspepsia with gastric emptying time in ESRD patients undergoing hemodialysis (HD). Dyspepsia was assessed through the Porto Alegre Dyspeptic Symptoms Questionnaire (PADYQ). PADYQ's scores ≥ 6 classified participants as dyspeptic. The octanoic acid breath test using ¹³carbon was employed to assess the gastric emptying time. Based on the test, time in minutes to metabolize the first half of the ¹³carbon in the test meal (t1/2) was calculated. Association of dyspepsia with gastric emptying time was tested by the correlation between PADYQ scores and t1/2, and also by comparing t1/2 between dyspeptics and non-dyspeptics. There were 34 (68.0%) dyspeptic patients. Dyspepsia score was positively correlated with t1/2 (r = 0.366; p = 0.009). Dyspeptics had longer t1/2 compared to non-dyspeptics, respectively, 238.0 ± 92.9 versus 185.5 ± 45.5 minutes (p = 0.042). Delayed gastric emptying was associated with dyspepsia. Prokinetic medications could have a role in preventing or relieving dyspeptic symptoms among HD patients. Future research in larger samples is necessary ...Continue Reading

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Citations

Apr 10, 2015·Nephrology·Paulo Roberto SantosRita de Cássia Parente Prado
Nov 7, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alison MargolskeeBertil Abrahamsson
Sep 21, 2017·Experimental Physiology·Daniel Maia Nogueira de OliveiraPedro Jorge Caldas Magalhães
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Jul 17, 2021·Indian Journal of Nephrology·Madapathi Sampath KumarSreejith Parameswaran
Nov 28, 2021·International Urology and Nephrology·Batric BabovicSnezana Radovanovic

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Software Mentioned

PADYQ
SPSS

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