PMID: 11929402Apr 4, 2002Paper

Dyspepsia tolerability from the patients' perspective: a comparison of celecoxib with diclofenac

Alimentary Pharmacology & Therapeutics
J L GoldsteinG S Geis

Abstract

To compare celecoxib (800 mg/day, n=1997) with diclofenac (150 mg/day, n=1996) on dyspepsia-related tolerability. In one of the two protocols comprising the Celecoxib Long-Term Arthritis Safety Study, a randomized double-blind trial, patients completed the Severity of Dyspepsia Assessment Questionnaire at baseline and at weeks 4, 13, 26 and 52 for the following three scales: Pain Intensity, Non-Pain Symptoms and Satisfaction with Dyspepsia-Related Health. For the Pain Intensity scale, patients given diclofenac had significantly higher (worsening dyspepsia) mean changes, defined as follow-up minus baseline, than patients given celecoxib (P < 0.001, at all assessments). The mean changes in the Pain Intensity scale (scale, 2-47; higher score is higher pain intensity) were 0.99 (95% confidence interval (CI): 0.50, 1.48) for celecoxib and 2.76 (95% CI: 2.28, 3.25) for diclofenac at 4 weeks. Satisfaction was superior with celecoxib at all assessments (P < 0.001). At 4 weeks, the mean changes in the Satisfaction scale (scale, 7-35; higher score is higher satisfaction) were 0.02 (95% CI: - 0.26, 0.29) for celecoxib and - 0.72 (95% CI: - 1.00, - 0.45) for diclofenac. Diclofenac patients had significantly higher Non-Pain Symptoms at 4 we...Continue Reading

References

Apr 1, 1989·Journal of Clinical Gastroenterology·E N LarkaiD Y Graham
Mar 1, 1970·Arthritis and Rheumatism·C Ranawat, L R Straub
May 8, 1998·The American Journal of Medicine·M R Griffin
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Mar 17, 2001·Scandinavian Journal of Rheumatology·F McKennaG S Geis

❮ Previous
Next ❯

Citations

Jul 6, 2007·BMC Gastroenterology·Michael LoydPhilip Jacobs
Feb 15, 2013·Clinical Drug Investigation·Roberto LabiancaDiego Fornasari
Nov 12, 2013·Applied Health Economics and Health Policy·Ronald C WielageMichael Happich
Feb 13, 2009·Current Medical Research and Opinion·Liviu NiculescuSharon Mallen
Jun 12, 2010·Pediatric Clinics of North America·Cynthia L Feucht, Dilip R Patel
Jul 14, 2005·Alimentary Pharmacology & Therapeutics·A PilottoUNKNOWN Sofia Project Investigators
May 28, 2008·Pharmacotherapy·Christopher M HerndonUNKNOWN Ambulatory Care, Cardiology, and Pain and Palliative Care Practice and Research Networks of the American College of Clinical
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L BuenoN J Talley
Apr 20, 2016·Arthritis·Amit GargShyam Akku
Nov 16, 2005·Gastroenterology·Samir Gupta, Kenneth McQuaid
Jun 10, 2017·The Cochrane Database of Systematic Reviews·Mahir FidahicLivia Puljak
May 8, 2018·Journal of Digestive Diseases·Hooi Leng LeeSanjiv Mahadeva
Jun 21, 2006·Journal of Cardiovascular Pharmacology·Loren Laine
Aug 6, 2009·European Journal of Gastroenterology & Hepatology·Gerard ThiéfinRené-Marc Flipo
Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jørgen Naesdal, Kurt Brown
May 12, 2009·Annals of Medicine·Richard H HuntCarmelo Scarpignato
Mar 6, 2012·Clinical Drug Investigation·Roberto LabiancaDiego Fornasari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved