Dyspeptic symptoms associated with hypersensitivity to gastric distension induced by duodenal acidification

Journal of Gastroenterology and Hepatology
K J LeeSung Won Cho

Abstract

Duodenal acidification might increase sensitivity to gastric distension, which seems to play a role in the genesis of dyspeptic symptoms in a subset of patients with functional dyspepsia. The aim of the present study was to investigate the characteristics of dyspeptic symptoms associated with hypersensitivity to gastric distension induced by duodenal acidification. An infusion tube and a barostat bag were positioned in the duodenum and gastric fundus, respectively. Sensitivity to stepwise fundic distensions with severity scoring of the seven dyspeptic symptoms was assessed before and during duodenal acid infusion in 20 healthy subjects. Acid infusion significantly decreased the pressures and the corresponding wall tensions at the thresholds for discomfort. At the distending level of minimal distending pressure (MDP) + 2 mmHg, significantly higher scores of fullness and bloating were obtained during acid infusion. With distending stimuli of MDP + 4 and 6 mmHg, fullness, bloating, nausea, satiety, epigastric burning and epigastric pain were significantly more severe during acid infusion than before acid infusion. At the level of MDP + 8 mmHg, the severity of epigastric pain was significantly greater, compared with that before aci...Continue Reading

References

Dec 1, 1989·Journal of Clinical Gastroenterology·N J TalleyD W Piper
May 1, 1995·Scandinavian Journal of Gastroenterology·M BortolottiL Barbara
Jun 1, 1997·Digestive Diseases and Sciences·B D MaesP J Rutgeerts
Aug 1, 1997·Gastroenterology·A M AccarinoJ R Malagelada
Jul 4, 1998·Digestive Diseases and Sciences·J KoskenpatoM Färkkilä
Aug 24, 1999·Gut·N J TalleyG N Tytgat
Sep 25, 2001·The American Journal of Gastroenterology·M P SchwartzA J Smout
Jan 29, 2002·The American Journal of Gastroenterology·G E BoeckxstaensG N J Tytgat
May 10, 2003·The American Journal of Gastroenterology·Giovanni SarnelliJan Tack
May 23, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kwang-Jae LeeJan Tack

❮ Previous
Next ❯

Citations

Oct 21, 2006·Current Opinion in Gastroenterology·Mamie H Dong, Jonathan D Kaunitz
Aug 4, 2010·Journal of Neurogastroenterology and Motility·Kwang Jae Lee, Jan Tack
Dec 21, 2011·Journal of Gastroenterology·Yoshikazu KinoshitaUNKNOWN FUTURE study group
Jul 26, 2012·Journal of Gastroenterology·Wataru IwaiTooru Shimosegawa
Mar 27, 2007·Digestive Diseases and Sciences·Motoyasu KusanoMasatomo Mori
Apr 3, 2012·The American Journal of Emergency Medicine·Khrongwong MusikatavornAtthasit Komindr
Nov 23, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J C Y WuF K L Chan
Jan 15, 2015·Journal of Gastroenterology·Hiroto MiwaUNKNOWN Japanese Society of Gastroenterology
Jan 16, 2013·Nature Reviews. Gastroenterology & Hepatology·Hanne Vanheel, Ricard Farré
May 25, 2018·Journal of Neurogastroenterology and Motility·Hye-Kyung Jung, Nicholas J Talley
Mar 18, 2010·The American Journal of Gastroenterology·O S van BoxelA J P M Smout
Apr 7, 2020·Expert Opinion on Therapeutic Targets·Lucas WautersNicholas J Talley
Nov 12, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shaoqi DuanYi Dai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.