Dysplasia in the mucosal biopsy specimen is still a warning sign of cancer in ulcerative colitis.

Scandinavian Journal of Gastroenterology
Essi K KarjalainenAnna H Lepistö

Abstract

Patients with ulcerative colitis are at increased risk for colorectal cancer, especially at younger ages. Our aim was to determine, in our patient cohort, the clinicopathological features, incidence, and prognosis of ulcerative colitis-associated colorectal cancer. A single-center, population-based study including all 1241 patients with ulcerative colitis who underwent surgery in Helsinki University Hospital, 1991-2018. All data were from medical records, collected retrospectively. In total, 71 patients with ulcerative colitis-associated cancer were operated on in Helsinki University Hospital during 1991-2018; 108 patients undergoing surgery during 2002-2018 showed dysplasia in the surgical specimen. Cancer was diagnosed preoperatively in 47 patients (66.2%). Ten patients (14.1%) had synchronous colorectal cancer, and 24 (33.8%) had synchronous dysplasia. The incidence of colorectal cancer has not changed during the study period (p = .113). Overall survival was 71.8%, and the 5-year colorectal cancer-specific survival was 81.5%. The incidence of ulcerative colitis-associated colorectal cancer remained constant in our study population over three decades. The prognosis of ulcerative colitis-associated colorectal cancer and the pr...Continue Reading

References

Mar 11, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Thierry DelaunoitEdward V Loftus
Sep 18, 2010·Inflammatory Bowel Diseases·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Oct 18, 2013·Scandinavian Journal of Gastroenterology·Airi JussilaMartti A Färkkilä
Mar 13, 2014·Alimentary Pharmacology & Therapeutics·C Castaño-MillaJ P Gisbert
Dec 4, 2014·World Journal of Gastroenterology : WJG·Masakazu Yashiro

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