Dysplasia severity is associated with poor quality of life in patients with Barrett's esophagus referred for endoscopic eradication therapy

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
S HanS Wani

Abstract

Limited data exist regarding patient-reported outcomes and quality of life (QOL) experienced by patients with Barrett's esophagus (BE) referred for endoscopic eradication therapy (EET). Specifically, the impact of grade of dysplasia has not been explored. The purpose of this study is to measure patient-reported symptoms and QOL and identify factors associated with poor QOL in BE patients referred for EET. This was a prospective multicenter study conducted from January 2015 to October 2017, which included patients with BE referred for EET. Participants completed a set of validated questionnaires to measure QOL, symptom severity, and psychosocial factors. The primary outcome was poor QOL defined by a PROMIS score >12. Multivariable logistic regression analysis was performed to identify factors associated with poor QOL. In total, 193 patients participated (mean age 64.6 years, BE length 5.5 cm, 82% males, 92% Caucasians) with poor QOL reported in 104 (53.9%) participants. On univariate analysis, patients with poor QOL had lower use of twice daily proton pump inhibitor use (61.5% vs. 86.5%, P = 0.03), shorter disease duration (4.9 vs. 5.9 years, P = 0.04) and progressive increase in grade of dysplasia (high-grade dysplasia: 68.8% v...Continue Reading

References

May 1, 1989·Gastroenterology·W HameetemanJ G van den Tweel
Feb 1, 1987·Journal of Clinical Gastroenterology·D A JohnsonE L Cattau
Mar 18, 1999·The New England Journal of Medicine·J LagergrenO Nyrén
Jul 23, 2003·The American Journal of Gastroenterology·Jonathan FletcherKenneth E L McColl
Mar 28, 2006·Journal of Anxiety Disorders·Norman B SchmidtKathleen Kara Fitzpatrick
Jun 23, 2009·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ron D HaysDavid Cella
Oct 5, 2010·Endoscopy·N J ShaheenUNKNOWN AIM Dysplasia Trial Investigators
Jan 8, 2013·Alimentary Pharmacology & Therapeutics·C JonassonJ G Hatlebakk
Nov 16, 2016·Health and Quality of Life Outcomes·Chi-Yang ChangJaw-Town Lin
Jan 28, 2017·BMC Medical Research Methodology·Gabriele Helga FrankeElmar Braehler
Feb 15, 2017·The American Journal of Gastroenterology·Srinadh KomanduriJohn Pandolfino
Feb 6, 2018·Gastrointestinal Endoscopy·UNKNOWN Standards of Practice CommitteeJohn Dewitt

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Citations

Nov 9, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mirjam C M van der Ende-van LoonE J Schoon

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