Dysplasias of uterine cervix: epidemiological aspects: role of age at first coitus and use of oral contraceptives
Age at first coitus and use of oral contraceptives were studied in a highly homogeneous population (French Canadian) during a cytologic cervical cancer screening program. Both factors were known in 84,540 women without cervical lesions and in 2017 patients with mild and moderate dysplasia. Highly significant correlations were found between: early onset of sexual activity and occurrence of dysplasia; oral contraceptive use and occurrence of dysplasia; early age at first coitus and oral contraceptive use. When correlated for age at first coitus, there was a significant excess of dysplasias in oral contraceptive users. Dysplasia of the uterine cervix behaves epidemiologically like carcinoma in situ and invasive squamous carcinoma, that is, essentially as a venereal disease. It remains to be seen whether all dysplasias form one continuum or whether there are two morphologically similar but biologically distinct forms of dysplasia: one more frequent, regressing spontaneously, the other relatively rare, progressing to carcinoma in situ and invasive squamous carcinoma of the cervix.
The impact of hormonal contraceptive therapy on a community and effects on cytopathology of the cervix
An epidemiologic study of cervical neoplastic disease. Based on a self-selected sample of 7,000 women in Barbados, West Indies
Prevalence rates of uterine cervical carcinoma in situ for women using the diaphragm or contraceptive oral steroids
Cervical cancer screening practices among older women: results from the Maryland Cervical Cancer Case-Control Study
Pap Smear Combined with HPV Testing: A Reasonable Tool for Women with High-grade Cervical Intraepithelial Neoplasia Treated by LEEP
Is it safe to prescribe hormonal contraception and replacement therapy to patients with premalignant and malignant uterine cervices?
Carcinoma, Squamous Cell
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