PMID: 589567Dec 1, 1977

Dysplasias of uterine cervix: epidemiological aspects: role of age at first coitus and use of oral contraceptives

Cancer
A MeiselsV Schneider

Abstract

Age at first coitus and use of oral contraceptives were studied in a highly homogeneous population (French Canadian) during a cytologic cervical cancer screening program. Both factors were known in 84,540 women without cervical lesions and in 2017 patients with mild and moderate dysplasia. Highly significant correlations were found between: early onset of sexual activity and occurrence of dysplasia; oral contraceptive use and occurrence of dysplasia; early age at first coitus and oral contraceptive use. When correlated for age at first coitus, there was a significant excess of dysplasias in oral contraceptive users. Dysplasia of the uterine cervix behaves epidemiologically like carcinoma in situ and invasive squamous carcinoma, that is, essentially as a venereal disease. It remains to be seen whether all dysplasias form one continuum or whether there are two morphologically similar but biologically distinct forms of dysplasia: one more frequent, regressing spontaneously, the other relatively rare, progressing to carcinoma in situ and invasive squamous carcinoma of the cervix.

Citations

Aug 1, 1984·The British Journal of Venereal Diseases·K SyrjänenS Saarikoski
Jan 27, 2009·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Paula J Adams Hillard
Dec 2, 2015·Infectious Agents and Cancer·Gabriela Elizabeth Campos-ViguriGloria Fernández-Tilapa
Jan 1, 1986·Journal of Chronic Diseases·L A Brinton, J F Fraumeni
Sep 1, 1987·American Journal of Epidemiology·D A Grayson
Oct 1, 1981·Gynecologic Oncology·A Meisels, C Morin
Jul 15, 1985·International Journal of Cancer. Journal International Du Cancer·W C ReevesR C De Britton
Apr 15, 1986·International Journal of Cancer. Journal International Du Cancer·W E RawlsM M Brenes
Jul 15, 1981·Cancer·J W Berg, J G Lampe
Dec 1, 1978·Pain·M Renaer, G M Guzinski
Mar 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·I MedhatR Fruchter
Jul 1, 1995·International Journal of STD & AIDS·M MurphyF M Mulcahy

Related Concepts

Intraepithelial Neoplasia
Squamous Cell Carcinoma
Cervical Dysplasia
Cervix Carcinoma
First Intercourse
Oral Contraceptives, Phasic

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