Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: A preliminary study

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Sachin C SarodeGargi S Sarode

Abstract

The grading of oral epithelial dysplasia (OED) is not applicable to oral submucous fibrosis (OSMF) cases due to the presence of atrophic epithelium. The mucosal margins associated with resected OSCC specimens are often closely related to transformed cells. In this study, we compared the histomorphological alterations (dysplastic features) in the atrophic epithelium of OSMF patients with the mucosal margins of OSCC associated with OSMF (OSCC-OSMF). We evaluated 17 dysplastic features in 37 patients with OSMF (biopsy site: buccal mucosa) and 37 patients with OSCC-OSMF (mucosal margins involving buccal mucosa) using histopathological staining. Dysplastic features, such as keratin pearls within rete ridges, nuclear pleomorphism, and atypical mitotic figures, were not observed in the epithelium of the OSMF or OSCC-OSMF groups. Basal cell hyperplasia (P = .016), abnormal superficial mitosis (P = .010), increased nuclear-cytoplasmic ratio (P = .034), and hyperchromasia (P = .031) were predominantly seen in the OSCC-OSMF group. We found no statistically significant differences in the following parameters: irregular epithelial stratification (P = 1.00), loss of basal cell polarity (P = .237), presence of drop-shaped rete ridges (P = .07...Continue Reading

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Citations

Jul 17, 2018·Pathology Oncology Research : POR·A Thirumal RajGargi S Sarode
Jul 22, 2019·Journal of Investigative and Clinical Dentistry·Amol R GadbailShankargouda Patil
Oct 31, 2020·Medical Hypotheses·Gargi SarodeShankargouda Patil
Mar 9, 2021·Expert Review of Molecular Diagnostics·Kenneth P H PritzkerDavid Mock
May 18, 2021·Journal of Oral Biology and Craniofacial Research·Sachin C SarodeShankargouda Patil

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