Dysplastic Lipoma: A Distinctive Atypical Lipomatous Neoplasm With Anisocytosis, Focal Nuclear Atypia, p53 Overexpression, and a Lack of MDM2 Gene Amplification by FISH; A Report of 66 Cases Demonstrating Occasional Multifocality and a Rare Association With Retinoblastoma

The American Journal of Surgical Pathology
Michael MichalJohn F Fetsch

Abstract

In our routine and consultative pathology practices, we have repeatedly encountered an unusual subcutaneous fatty tumor with notable anisocytosis, single-cell fat necrosis, and patchy, often mild, adipocytic nuclear atypia. Because of the focal atypia, consultative cases have most often been received with concern for a diagnosis of atypical lipomatous tumor. Similar tumors have been described in small series under the designations "subcutaneous minimally atypical lipomatous tumors" and "anisometric cell lipoma." Sixty-six cases of this tumor type were collected and reviewed. Immunohistochemistry for p53, MDM2, CDK4, Retinoblastoma 1 (RB1) protein, CD34, S100, and CD163 was performed. Cases were tested for MDM2 gene amplification and RB1 gene deletion with fluorescence in situ hybridization (FISH) and for TP53 mutations by Sanger sequencing. Next-generation sequencing analysis using a panel of 271 cancer-related genes, including TP53, RB1, and MDM2, was also carried out. Our patient cohort included 57 male patients, 8 female patients, and 1 patient of unstated sex, who ranged in age from 22 to 87 years (mean: 51.2 y). All tumors were subcutaneous, with most examples occurring on the upper back, shoulders, or posterior neck (86.4...Continue Reading

References

Nov 1, 1975·Cancer·F M Enzinger, D A Harvey
Mar 1, 1987·The American Journal of Surgical Pathology·N AzumiM R Hendrickson
Nov 1, 1994·American Journal of Clinical Pathology·D R LucasM G Rock
Jun 27, 1998·Pathology·P W AllenL B MacCormac
Sep 12, 2000·Annals of Diagnostic Pathology·A P Dei Tos
Oct 17, 2001·American Journal of Clinical Pathology·Z K ArbiserS W Weiss
Jun 10, 2004·British Journal of Cancer·S BamfordR Wooster
Dec 25, 2004·The American Journal of Dermatopathology·Kenneth S Resnik, Heinz Kutzner
Dec 24, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Larisa V DebelenkoHarry P W Kozakewich
Jun 16, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takeshi KashimaAdrienne Margaret Flanagan
Aug 11, 2016·The American Journal of Surgical Pathology·Michael R ClayMark A Edgar
Aug 19, 2016·Nature·Monkol LekUNKNOWN Exome Aggregation Consortium
Nov 24, 2016·The American Journal of Surgical Pathology·Adrian Mariño-EnriquezChristopher D M Fletcher
May 27, 2017·Human Pathology·Michael MichalMichal Michal
Jul 19, 2017·The American Journal of Surgical Pathology·Jennifer S KoSteven D Billings
Nov 23, 2017·Nucleic Acids Research·Melissa J LandrumDonna R Maglott

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Citations

Sep 11, 2019·Virchows Archiv : an International Journal of Pathology·David Creytens
May 5, 2020·International Journal of Surgical Pathology·Michael A den BakkerWinand N M Dinjens
Jun 27, 2019·Der Pathologe·E Wardelmann, W Hartmann
Jan 18, 2020·Head and Neck Pathology·Wonwoo Shon, Steven D Billings
Sep 23, 2020·Advances in Anatomic Pathology·Joon Hyuk Choi, Jae Y Ro
Oct 6, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael MichalMichal Michal
Apr 4, 2021·Diagnostics·Sasha LibbrechtDavid Creytens
May 1, 2021·Cancers·Milo van Hoefen WijsardLindsay M Morton
Dec 28, 2021·Histopathology·Khin Thway

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Methods Mentioned

BETA
biopsy
dissection

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