Dysregulated enzymatic antioxidant network in peripheral neutrophils and monocytes in children with autism

Progress in Neuro-psychopharmacology & Biological Psychiatry
Ahmed NadeemSaleh A Bakheet

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder where immune cells play an important role. Oxidants and pro-inflammatory cytokines generated by innate immune cells have been implicated in the pathogenesis of ASD. Many previous reports have shown the role of various enzymatic antioxidants in the plasma/red blood cells of ASD subjects, however no study so far has evaluated them in peripheral immune cells of innate origin (neutrophils and monocytes) in ASD patients and typically developing control (TDC) children. With this background, our study explored the expression and activities of major enzymatic antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) in peripheral neutrophils and monocytes of TDC/ASD subjects. Our data show that expression and activity of SOD is increased in ASD subjects as compared to TDC children in neutrophils and monocytes. On the other hand, GPx/GR activity is either reduced/unaltered in neutrophils and monocytes of ASD subjects as compared to TDC children. Increased SOD expression is associated with upregulated expression of nitrotyrosine (a marker of oxidant damage) in both innate immune cells of ASD subjects. Our study suggests that...Continue Reading

Citations

Sep 5, 2019·Frontiers in Cellular Neuroscience·Lauren Rylaarsdam, Alicia Guemez-Gamboa
Feb 7, 2020·Molecular Neurobiology·Geir BjørklundSalvatore Chirumbolo
Aug 3, 2020·Molecular and Cellular Biochemistry·Arun MeyyazhaganRamon Cacabelos
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Tingting HuQingnan He
Aug 11, 2021·Autism Research : Official Journal of the International Society for Autism Research·Takahira YamauchiToshifumi Kishimoto

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