Dysregulated Epstein-Barr virus infection in patients with CIDP

Journal of Neuroimmunology
Jan D LünemannFrauke Zipp

Abstract

Ubiquitous viruses have frequently been proposed as a cause or trigger of chronic immune-mediated diseases. Infections are reported to be temporally associated with clinical exacerbations in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined immunological parameters of herpesvirus infections in untreated patients with CIDP compared to demographically matched controls. Patients with CIDP were uniformly seropositive for EBV-specific IgG and the disease was associated with a moderately enhanced IgG reactivity to EBV-encoded antigens expressed during both B cell transformation and productive viral replication. Moreover, cellular EBV copy numbers were 3-fold increased in patients with CIDP. In contrast, humoral immune responses to other herpesviruses (HCMV, HSV) as well as virus-specific IgM responses were unchanged in CIDP. These data indicate that host-pathogen interactions during chronic EBV infection are dysregulated in treatment-naïve patients with CIDP.

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Citations

Jan 6, 2018·Journal of Family Medicine and Primary Care·Madhulika MistryGarima Mehta
Apr 20, 2018·The Journal of Dermatology·Shin IinumaAkemi Ishida-Yamamoto
Mar 23, 2019·Pathology Oncology Research : POR·Kumar SangamShashi Anand
Sep 11, 2020·Journal of the Neurological Sciences·Samir Abu-RumeilehMakbule Senel
Jul 30, 2021·Journal of Neuroimmunology·G G A van LieverlooF Eftimov
Sep 2, 2021·Zeitschrift für Rheumatologie·Martin SchillerWolfgang Kick

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