Dysregulated ErbB4 Splicing in Schizophrenia: Selective Effects on Parvalbumin Expression

The American Journal of Psychiatry
Daniel W ChungDavid A Lewis

Abstract

Alternative splicing of ErbB4 transcripts is dysregulated in the dorsolateral prefrontal cortex in schizophrenia. ErbB4 regulates the activity of parvalbumin interneurons, and therefore dysregulated ErbB4 splicing could contribute to lower parvalbumin interneuron activity and consequently lower parvalbumin levels in schizophrenia. However, ErbB4 is also present in calretinin interneurons, which are not affected in schizophrenia. Therefore, the authors hypothesized that dysregulated ErbB4 splicing occurs selectively in parvalbumin interneurons and is associated with lower parvalbumin levels in schizophrenia. Tissue samples enriched in calretinin and parvalbumin interneurons were laser microdissected from dorsolateral prefrontal cortex layers 2 and 4, respectively, from matched pairs of schizophrenia and comparison subjects. Transcript levels for pan-ErbB4, four ErbB4 splicing variants (JM-a, JM-b, CYT-1, CYT-2), parvalbumin, and calretinin were quantified by quantitative polymerase chain reaction (qPCR) in each layer. Transcript levels for myocardial infarction associated transcript (MIAT), which regulates ErbB4 splicing, were quantified in gray matter by qPCR and in parvalbumin interneurons by microarray. Calretinin and parvalb...Continue Reading

Citations

Jun 11, 2016·Neuroscience and Biobehavioral Reviews·Md Shaki MostaidChad A Bousman
Jan 12, 2017·The Journal of Comparative Neurology·Jill R GlausierDavid A Lewis
Jan 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Daniel W ChungDavid A Lewis
Nov 12, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Enrique Lara-PezziMaría Victoria Gómez-Gaviro
Nov 8, 2017·Molecular Psychiatry·J F Enwright IiiD A Lewis
Sep 19, 2019·Journal of Neural Transmission·Stephen J KaarOliver D Howes
Jul 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiaxun NieXiaowei Guan
Jun 1, 2017·NPJ Schizophrenia·Kazu NakazawaKazuhito Nakao
Aug 19, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel W ChungDavid A Lewis
Jul 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob B RudenChristine Konradi
Dec 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hongsheng WangLin Mei
Nov 12, 2020·Molecular Psychiatry·Sumin YangJae-Yeol Joo
Apr 16, 2021·Cell Death & Disease·Peng ChenBing-Xing Pan
Jul 22, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jason SmucnyCameron S Carter
Sep 17, 2021·Epigenomics·Jiao JiaYan Ren
Sep 25, 2021·Psychiatry and Clinical Neurosciences·Yoji Hirano, Peter J Uhlhaas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.