Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents

Frontiers in Oncology
Jose L DaniottiAldo A Vilcaes

Abstract

Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of vertebrate plasma membranes. Changes in the expression of certain species of gangliosides have been described to occur during cell proliferation, differentiation, and ontogenesis. However, the aberrant and elevated expression of gangliosides has been also observed in different types of cancer cells, thereby promoting tumor survival. Moreover, gangliosides are actively released from the membrane of tumor cells, having a strong impact on impairing anti-tumor immunity. Beyond the undesirable effects of gangliosides in cancer cells, a substantial number of cancer immunotherapies have been developed in recent years that have used gangliosides as the main target. This has resulted in successful immune cell- or antibody-responses against glycolipids, with promising results having been obtained in clinical trials. In this review, we provide a general overview on the metabolism of glycolipids, both in normal and tumor cells, as well as examining glycolipid-mediated immune modulation and the...Continue Reading

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T M KloppelD J Morré
Dec 14, 1978·Biochemical and Biophysical Research Communications·J PortoukalianJ F Doré
Jan 1, 1991·International Reviews of Immunology·M H Ravindranath, D L Morton
Mar 1, 1989·Immunology Letters·D S HoonW H McBride
Jul 24, 1974·Biochemical and Biophysical Research Communications·G YogeeswaranS Hakomori
Jan 1, 1981·Annual Review of Biochemistry·S Hakomori
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
May 1, 1996·Clinical Immunology and Immunopathology·H Kimata, A Yoshida
May 13, 1996·FEBS Letters·R Olshefski, S Ladisch
Jul 1, 1996·CA: a Cancer Journal for Clinicians·D L Morton, A Barth
Sep 27, 1996·Biochimica Et Biophysica Acta·A Heitger, S Ladisch
Aug 1, 1997·Melanoma Research·M L NasiP B Chapman
Jun 2, 1998·Cellular Immunology·J ZhouS J Ewald
Nov 18, 1998·The Journal of Allergy and Clinical Immunology·N Kanda, K Tamaki
Mar 5, 1999·Biochimica Et Biophysica Acta·H J MaccioniJ A Martina
Jun 8, 1999·Annual Review of Immunology·S A Porcelli, R L Modlin
Sep 24, 1999·The Journal of Clinical Investigation·R G UzzoJ H Finke
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·T GilewskiS J Danishefsky
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mauro AlfonsoAna María Vázquez
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Venkataraman SriramRandy R Brutkiewicz
Nov 28, 2002·Clinical and Experimental Immunology·M WölflF Berthold
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tadashi YamashitaRichard L Proia
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josette Péguet-NavarroJacques Portoukalian
Jun 14, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Konrad Sandhoff, Thomas Kolter
Jun 14, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard L Proia
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sheila CaldwellStephan Ladisch
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pam TangvoranuntakulElaine Muchmore
Dec 20, 2003·Nature·Kentaro HanadaMasahiro Nishijima
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark V ThorntonJames H Finke
Jul 2, 2004·Glycoconjugate Journal·G Tettamanti
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia RaymanJames Finke
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dzung H NguyenAjit Varki
Jul 22, 2005·Immunology and Cell Biology·Susan F SlovinGovind Ragupathi
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weiping ShenStephan Ladisch

❮ Previous
Next ❯

Citations

Sep 1, 2016·Mediators of Inflammation·Edismauro Garcia Freitas FilhoMaria Célia Jamur
Mar 16, 2017·Chembiochem : a European Journal of Chemical Biology·Sophie Groux-DegrootePhilippe Delannoy
May 10, 2017·International Journal of Molecular Sciences·Fabio Dall'Olio, Marco Trinchera
Mar 22, 2019·International Journal of Molecular Sciences·Emma Scott, Jennifer Munkley
May 6, 2019·Breast Cancer Research and Treatment·Evan N CohenJames M Reuben
Sep 8, 2019·Journal of Biomedical Science·Ricardo Dante LardoneGustavo Alejandro Nores
Dec 25, 2019·The Journal of Cell Biology·Alexander Buffone, Valerie M Weaver
Feb 13, 2020·Biotechnology & Genetic Engineering Reviews·Thomas E MacCalmanStephen E Harding
Feb 9, 2020·International Journal of Molecular Sciences·Aldo A VilcaesJose L Daniotti
Aug 29, 2020·Journal of Immunology Research·Corina Daniela EneSimona Roxana Georgescu
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Theresa D AhrensMette Ø Agerbæk
Apr 7, 2021·Critical Reviews in Biochemistry and Molecular Biology·Shuhui ChenLara K Mahal

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM2

Methods Mentioned

BETA
glycosylations

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cellular Immunometabolism

Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.