PMID: 9178800May 16, 1997Paper

Dysregulated expression of transforming growth factor beta and its type-I and type-II receptors in basal-cell carcinoma

International Journal of Cancer. Journal International Du Cancer
M FurueK Tamaki

Abstract

In mammals, transforming growth factor-beta (TGF-beta) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type-I and type-II receptors (TbetaR-I and TbetaR-II). TGF-beta regulates the growth and metabolism of various cell types, including keratinocytes. We have investigated the immunohistological localization of TGF-beta1, TGF-beta2, TbetaR-I and TbetaR-II in normal human skin, basal-cell carcinoma (BCC), Bowen's disease, seborrheic keratosis, eccrine poroma and eccrine spiradenoma using frozen tissue specimens. In normal human skin, the immunoreactive TGF-beta2, but not TGF-beta1, was detected predominantly in the epidermis, follicles and sebaceous glands. The epidermal expression of TbetaR-I and TbetaR-II was very weak in the majority of normal skins. In BCC, TGF-beta2 expression was markedly reduced or completely negative. In addition, TbetaR-I- and TbetaR-II-positive stromal cells were accumulated in the fibrotic stroma in some BCCs. These stromal cells were partly but moderately positive for TGF-beta1. Decreased expression of TGF-beta2 was likely to be associated with the differentiation state of BCC cells, since TGF-beta2 expression was clearly observed in the squamoid foci of B...Continue Reading

References

May 1, 1992·Journal of Dermatological Science·V FalangaG A Ksander
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Dec 1, 1994·Trends in Biochemical Sciences·R Derynck
Aug 1, 1994·Journal of Dermatological Science·M Wataya-KanedaK Yoshikawa
Aug 4, 1994·Nature·J L WranaJ Massagué

❮ Previous
Next ❯

Citations

Jan 25, 2013·BMC Dermatology·Adrian J McNairnGéraldine Guasch
Jun 13, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·I FlisiakB Chodynicka
Nov 4, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Iwona FlisiakBozena Chodynicka
Oct 24, 2007·Pathology, Research and Practice·Angelica A SaettaKiriaki Aroni
Oct 2, 2007·Dermatologic Clinics·Uwe WollinaChristos C Zouboulis
Jul 1, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·I FlisiakB Chodynicka
Sep 8, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A LallyF Wojnarowska
Nov 7, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Iwona FlisiakBozena Chodynicka
Nov 9, 2002·The Australasian Journal of Dermatology·Tony DickerNicholas Saunders
Feb 15, 2001·Microscopy Research and Technique·X J Wang
Aug 22, 2018·Oncology Letters·Magdalena CiążyńskaAleksandra Lesiak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.